Synthesis of new conjugated coumarin-benzimidazole hybrids and their anticancer activity

被引：128
|
作者：
Paul, Kamaldeep [1 ]
Bindal, Shweta [1 ]
Luxami, Vijay [1 ]
机构：
[1] Thapar Univ, Sch Chem & Biochem, Patiala 147004, Punjab, India
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2013年 / 23卷 / 12期
关键词：
Coumarin; Benzimidazole; Hybrids; Anticancer agents; Molecular docking; VIRUS NS5B POLYMERASE; NATIONAL-CANCER-INSTITUTE; DRUG DISCOVERY; IN-VITRO; ANTITUMOR-ACTIVITY; DERIVATIVES; INHIBITORS; DESIGN; POTENT; ACID;
D O I：
10.1016/j.bmcl.2012.12.071
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A series of novel coumarin-benzimidazole hybrids, 3-(1H-benzo[d]imidazol-2-yl)-7-(substituted amino)-2H-chromen-2-one derivatives of biological interest were synthesized. Six out of the newly synthesized compounds were screened for in vitro antitumor activity against preliminary 60 tumor cell lines panel assay. A significant inhibition for cancer cells was observed with compound 8 (more than 50% inhibition) compared with other compounds and active known drug 5-fluorouracil (in some cell lines) as positive control. Compound 8 displayed appreciable anticancer activities against leukemia, colon cancer and breast cancer cell lines. (C) 2013 Elsevier Ltd. All rights reserved.
引用
收藏
页码：3667 / 3672
页数：6
相关论文
共 50 条
  • [1] Synthesis and fluorescent properties of coumarin-benzimidazole and coumarin-phenanthroimidazole hybrids
    Fan, Hongli
    Wang, Lingqiang
    Wang, Xiaolong
    [J]. JOURNAL OF CHEMICAL RESEARCH, 2020, 44 (1-2) : 9 - 13
  • [2] Coumarin-benzimidazole hybrids as a potent antimicrobial agent: synthesis and biological elevation
    Singh, L. Ravithej
    Avula, Srinivasa Rao
    Raj, Sneha
    Srivastava, Akanksha
    Palnati, Gopala Reddy
    Tripathi, C. K. M.
    Pasupuleti, Mukesh
    Sashidhara, Koneni V.
    [J]. JOURNAL OF ANTIBIOTICS, 2017, 70 (09): : 954 - 961
  • [3] Coumarin-benzimidazole hybrids: A review of developments in medicinal chemistry
    Arya, C. G.
    Gondru, Ramesh
    Li, Yupeng
    Banothu, Janardhan
    [J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022, 227
  • [4] Design and synthesis of novel coumarin-benzimidazole hybrids as human galectin-1 inhibitors
    Nerella, Sridhar G.
    Alvala, Ravi
    Kalle, Arunasree M.
    Alvala, Mallika
    [J]. FUTURE MEDICINAL CHEMISTRY, 2024, 16 (09) : 843 - 857
  • [5] Design, synthesis and anticancer activity of Novel benzimidazole containing quinoline hybrids
    Srinivasa, Shashidhar Bharadwaj
    Poojary, Boja
    Kalal, Bhuvanesh Sukhlal
    Brahmavara, Usha
    Vaishali, Dhanashri
    Das, Anupam J.
    Kalenga, Thobias Mwalingo
    Paidikondala, Maruthibabu
    Shankar, Madan Kumar
    [J]. RESULTS IN CHEMISTRY, 2024, 9
  • [6] Synthesis of new benzimidazole and phenylhydrazinecarbothiomide hybrids and their anticonvulsant activity
    Siddiqui, Nadeem
    Alam, Md. Shamsher
    Ali, Ruhi
    Yar, M. Shahar
    Alam, Ozair
    [J]. MEDICINAL CHEMISTRY RESEARCH, 2016, 25 (07) : 1390 - 1402
  • [7] Synthesis of new benzimidazole and phenylhydrazinecarbothiomide hybrids and their anticonvulsant activity
    Nadeem Siddiqui
    Md. Shamsher Alam
    Ruhi Ali
    M. Shahar Yar
    Ozair Alam
    [J]. Medicinal Chemistry Research, 2016, 25 : 1390 - 1402
  • [8] Synthesis of New Coumarin-C3 Benzimidazole Hybrids and Their Urease Inhibition Studies
    Akyuz, Guelay
    Mentese, Emre
    [J]. LETTERS IN ORGANIC CHEMISTRY, 2023, 20 (09) : 864 - 870
  • [9] Synthesis and Antibacterial Activity of New Chiral Aminoalcohol and Benzimidazole Hybrids
    Cicek, Ilknur
    Tunc, Turgay
    Ogutcu, Hatice
    Abdurrahmanoglu, Suzan
    Gunel, Aslihan
    Demirel, Nadir
    [J]. CHEMISTRYSELECT, 2020, 5 (15): : 4650 - 4654
  • [10] Synthesis of benzimidazole nucleosides and their anticancer activity
    Shinde, Vaishali S.
    Lawande, Pravin P.
    Sontakke, Vyankat A.
    Khan, Ayesha
    [J]. CARBOHYDRATE RESEARCH, 2020, 498 (498)
12345