Immunomodulation and the quorum sensing molecule 3-oxo-C12-homoserine lactone: the importance of chemical scaffolding for probe development

被引：4
|
作者：
Garner, Amanda L. [1 ,2 ,3 ]
Yu, Jing [1 ,2 ,3 ]
Struss, Anjali K. [1 ,2 ,3 ]
Kaufmann, Gunnar F. [1 ,2 ,3 ]
Kravchenko, Vladimir V. [4 ]
Janda, Kim D. [1 ,2 ,3 ]
机构：
[1] Scripps Res Inst, Skaggs Inst Chem Biol, Dept Chem, La Jolla, CA 92037 USA
[2] Scripps Res Inst, Skaggs Inst Chem Biol, Dept Immunol & Microbial Sci, La Jolla, CA 92037 USA
[3] Scripps Res Inst, Worm Inst Res & Med, La Jolla, CA 92037 USA
[4] Scripps Res Inst, Dept Immunol & Microbial Sci, La Jolla, CA 92037 USA
来源：
CHEMICAL COMMUNICATIONS | 2013年 / 49卷 / 15期
关键词：
N-3-OXODODECANOYL HOMOSERINE LACTONE; PSEUDOMONAS-AERUGINOSA INFECTION; NF-KAPPA-B; N-(3-OXODODECANOYL)-L-HOMOSERINE LACTONE; IMMUNE-RESPONSES; IN-VIVO; RECOGNITION; VIRULENCE; MODULATION; ACTIVATION;
D O I：
10.1039/c3cc38851d
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
As a guide for chemical probe design, focused analogue synthetic studies were undertaken upon the lactone ring of 3-oxo-C-12-homoserine lactone. We have concluded that hydrolytic instability of the heterocyclic ring is pivotal for its ability to modulate immune signaling and probe preparation was aligned with these findings.
引用
收藏
页码：1515 / 1517
页数：3
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