Synthesis of Ureido-Linked Glycosylated Amino Acids from Nα-Fmoc-Asp/Glu-5-oxazolidinones and Their Application to Neoglycopeptide Synthesis

被引：2

作者：

Sureshbabu, Vommina V. ^{[1
]}

Venkataramanarao, Rao ^{[1
]}

Naik, Shankar A. ^{[1
]}

Narendra, N. ^{[1
]}

机构：

[1] Bangalore Univ, Dept Studies Chem, Bangalore 560001, Karnataka, India

来源：

SYNTHETIC COMMUNICATIONS | 2008年 / 38卷 / 21期

关键词：

Curtius rearrangement; N-alpha-Fmoc-Asp/Glu-5-oxazolidinones; neoglycopeptides; ureido-linked glcosylated amino acids;

D O I：

10.1080/00397910802213711

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A simple route for the synthesis of ureido-linked glycosylated amino acids has been described. The key step involves the reaction of isocyanates derived from N-Fmoc-Asp/Glu-5-oxazolidinones 1 with glycosyl amines followed by hydrolysis. The resulting ureido-linked glycosylated amino acids have been incorporated into peptides. The overall procedure is simple, high-yielding, and involves fewer steps.

引用

页码：3640 / 3654

页数：15

共 44 条

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