Investigation of the applicability of fatty acid-based deep eutectic solvent based air assisted liquid liquid microextraction for the rapid determination and extraction of butylparaben in cosmetic products

In this research paper, fatty acid-based deep eutectic solvents (FA-DESs) were prepared and investigated for the extraction of butylparaben (BP) from cosmetic products by air assisted liquid liquid microextraction (AA-DLLME). The amounts of BP were determined by UV/Vis spectro-photometry. By combining single factor optimization and Box-Behnken design based multivariate approach, key extraction parameters affecting the FA-DES AA-LLME procedure were systemati-cally optimized. Under the optimized conditions, wide working range (5-800 mu g L-1) was ob-tained with a good r2:0.9972 and high enrichment factor (205). For three replications run of 10 mu g L-1 (low), 300 mu g L-1 (medium) and 600 mu g L-1 (high) of BP, the percent extraction recovery and relative standard deviation were in the range of 92 +/- 4%-98 +/- 2% and 1.8-2.6%, respec-tively. The limit of detection and the limit of quantification were 1.5 mu g L-1 and 5 mu g L-1, respectively. The study of the matrix effect showed that the proposed method has high selectivity for measuring BP in the selected samples. Therefore, it has great potential in sample pre-treatment and quantification of trace BP in cosmetic products.