Background: This systematic review and meta-analysis aimed to evaluate the wear of the antagonist tooth in ceramic restorations. Material and methods: This study was carried out based on Preferred Reporting Items for Systematic Review and Meta-analysis (PRISMA) recommendations; it was also registered in PROSPERO (register number: CRD42022316252). Three databases were consulted in the literature search, Embase, Scopus, and Web of Science. The citation searching was conducted by two researchers independently. The clinical studies that evaluated wear in antagonist teeth concerning ceramic restoration were included. Twelve articles were selected after eliminating duplicates ones and applying the inclusion criteria, and two were chosen through citation. Fourteen articles were considered for the qualitative and quantitative analysis (meta-regression and meta-analysis). Results: The mean linear wear of the antagonist tooth in relation to feldspathic was 8.914 mu m, for lithium disilicate it was 0.018 mu m, and for zirconia it was 0.257 mu m. The mean volumetric wear of the antagonist tooth in relation to feldspathic was 0.273 mm(3), for hybrid ceramic it was 0.030 mm(3), for lithium disilicate it was 0.018 mm(3), and for zirconia it was 0.014 mm(3). The mean natural tooth wear was 0.7974 mu m per month. Tooth wear caused by zirconia at six months was 31.755 mu m, at 12 months it was 24.648 mu m, and at 24 months it was 20.662 mu m. Conclusions: Feldspathic produces greater wear of the antagonist tooth from ceramic restorations linearly and volumetrically. In addition, zirconia generates the least wear that will decrease over time, and it will be equal to or less than the natural wear in the tooth.