Evaluation of acetylcholinesterase in an animal model of mania induced by D-amphetamine

被引：7
|
作者：
Varela, Roger B. [1 ,2 ]
Valvassori, Samira S. [1 ,2 ]
Lopes-Borges, Jessica [1 ,2 ]
Fraga, Daiane B. [1 ,2 ]
Resende, Wilson R. [1 ,2 ]
Arent, Camila O. [1 ,2 ]
Zugno, Alexandra I. [1 ,2 ]
Quevedo, Joao [1 ,2 ]
机构：
[1] Univ Southern Santa Catarina, Natl Inst Translat Med INCT TM, Grad Program Hlth Sci, Neurosci Lab,Hlth Sci Unit, BR-88806000 Criciuma, SC, Brazil
[2] Univ Southern Santa Catarina, Postgrad Program Hlth Sci, Hlth Sci Unit, Ctr Excellence Appl Neurosci Santa Catarina NENAS, BR-88806000 Criciuma, SC, Brazil
来源：
PSYCHIATRY RESEARCH | 2013年 / 209卷 / 02期
关键词：
Acetylcholinesterase; Animal model of mania; Lithium; Valproate; D-Amphetamine; INDUCED DOPAMINE RELEASE; PROTEIN-KINASE-C; BIPOLAR DISORDER; PREFRONTAL CORTEX; OXIDATIVE STRESS; CHOLINESTERASE-INHIBITORS; BEHAVIORAL-CHANGES; LITHIUM TREATMENT; RECEPTOR-BINDING; FRONTAL-CORTEX;
D O I：
10.1016/j.psychres.2012.11.021
中图分类号：
R749 [精神病学];
学科分类号：
100205 ;
摘要：
The present study aims to investigate the effects of mood stabilizers, lithium (Li) and valproate (VPA), on acetylcholinesterase (AChE) activity in the brains of rats subjected to an animal model of mania induced by D-amphetamine (D-AMPH). In the reversal treatment, Wistar rats were first given D-AMPH or saline (Sal) for 14 days. Between days 8 and 14, the rats were treated with Li, VPA, or Sal. In the prevention treatment, rats were pretreated with Li, VPA, or Sal. AChE activity was measured in the brain structures (prefrontal cortex, hippocampus, and striatum). Li, alone in reversion and prevention treatments, increased AChE activity in the brains of rats. VPA, alone in prevention treatment, increased AChE activity in all brain regions evaluated; in the reversion, only in the prefrontal. However, D-AMPH decreased activity of AChE in the striatum of rats in both the reversion and prevention treatments. VPA was able to revert and prevent this AChE activity alteration in the rat striatum. Our findings further support the notion that the mechanisms of mood stabilizers also involve changes in AChE activity, thus reinforcing the need for more studies to better characterize the role of acetylcholine in bipolar disorder. (c) 2012 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：229 / 234
页数：6
相关论文
共 50 条
  • [21] PARANOID PSYCHOSIS IN MAN INDUCED BY ADMINISTRATION OF D-AMPHETAMINE
    GRIFFITH, J
    CAVANAUGH, J
    OATES, J
    PHARMACOLOGIST, 1968, 10 (02): : 180 - +
  • [22] EFFECTS OF D-AMPHETAMINE ON SCHEDULE-INDUCED ESCAPE
    SLIFER, BE
    PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1978, 9 (05) : 609 - 614
  • [23] MATURATION AND D-AMPHETAMINE INDUCED CHANGES IN WEB BUILDING
    REED, CF
    WITT, PN
    SCARBORO, MB
    DEVELOPMENTAL PSYCHOBIOLOGY, 1982, 15 (01) : 61 - 70
  • [24] A STUDY ON THE ANTAGONISM OF D-AMPHETAMINE INDUCED LETHALITY BY TRANQUILIZERS
    SELVASUBRAMANIAN, S
    NATARAJAN, R
    CHEIRON, 1983, 12 (06): : 283 - 286
  • [25] Sleep disturbance induced by amphetamine in a rodent model of mania
    Andersen, M. L.
    Tufik, S.
    Margis, R.
    Frey, B. N.
    Giglio, L. M.
    Kapczinski, F.
    SLEEP, 2008, 31 : A319 - A319
  • [26] SUPERSENSITIVITY TO D-AMPHETAMINE-INDUCED AND APOMORPHINE-INDUCED STEREOTYPED BEHAVIOR INDUCED BY CHRONIC D-AMPHETAMINE ADMINISTRATION
    KLAWANS, HL
    MARGOLIN, DI
    DANA, N
    CROSSET, P
    JOURNAL OF THE NEUROLOGICAL SCIENCES, 1975, 25 (03) : 283 - 289
  • [27] AMPHETAMINE-INDUCED TASTE AVERSION - COMPARISON OF D-AMPHETAMINE VERSUS 1-AMPHETAMINE
    CAREY, RJ
    GOODALL, EB
    PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1974, 2 (03) : 325 - 330
  • [28] Doxycycline reverses cognitive impairment, neuroinflammation and oxidative imbalance induced by D-amphetamine mania model in mice: A promising drug repurposing for bipolar disorder treatment?
    Maia Chaves Filho, Adriano Jose
    Cunha, Natassia Lopes
    Rodrigues, Patricia de Araujo
    de Souza, Alana Gomes
    Soares, Michele Verde-Ramo
    Juca, Paloma Marinho
    de Queiroz, Tatiana
    da Silva Clemente, Dino Cesar
    Mottin, Melina
    Andrade, Carolina Horta
    Peixoto, Christina Alves
    Macedo, Danielle S.
    EUROPEAN NEUROPSYCHOPHARMACOLOGY, 2021, 42 : 57 - 74
  • [29] Coadministration of lithium and celecoxib attenuates the behavioral alterations and inflammatory processes induced by amphetamine in an animal model of mania
    Valvassori, Samira S.
    Dal-Pont, Gustavo C.
    Tonin, Paula T.
    Varela, Roger B.
    Ferreira, Camila L.
    Gava, Fernanda F.
    Andersen, Monica L.
    Soares, Jair C.
    Quevedo, Joao
    PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 2019, 183 : 56 - 63
  • [30] Female rats that rapidly acquire a d-amphetamine discrimination generalize more to d-amphetamine
    Tomie, A
    Mosakowski, EM
    PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1996, 54 (04) : 699 - 703
12345