Recent Advances in the Medicinal Chemistry of Aurones

被引：3

作者：

Haudecoeur, R. ^{[1
]}

Boumendjel, A. ^{[1
]}

机构：

[1] UJF Grenoble 1, CNRS, UMR 5063, Dept Pharmacochim Mol, F-38041 Grenoble 9, France

来源：

CURRENT MEDICINAL CHEMISTRY | 2012年 / 19卷 / 18期

关键词：

Alzheimer's disease; antioxidants; aureusidin; antiviral; aurones; cancer; cytotoxicity; flavonoids; hepatitis C; kinases; sulfuretin; tyrosinase; BETA-AMYLOID PLAQUES; VIRUS NEURAMINIDASE INHIBITORS; RADICAL SCAVENGING ACTIVITY; LIGAND-BINDING SITE; BREAST-CANCER CELLS; NF-KAPPA-B; ALZHEIMERS-DISEASE; NITRIC-OXIDE; IN-VITRO; NAD(P)H-QUINONE OXIDOREDUCTASE-1;

D O I：

暂无

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The first review regarding the potential of aurones as promising drug candidates was reported in 2003. Since, considerable efforts have been made to explore the pharmacological and therapeutical activities of aurones. In this regard, many biological areas were concerned, including major pathological, such as cancer and neurodegenerative disorders. The aim of the present report is to highlight the progress made during the last ten years on the medicinal chemistry of aurones. A special focus will be made on the structure-activity relationship aspects among aurones and especially in case where aurones were found highly active than the corresponding flavones and chalcones.

引用

页码：2861 / 2875

页数：15

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