FIP: a novel approach to vaccination - Proceedings from the 2nd International FCoV/FIP Symposium, Glasgow, 4-7 August 2002

被引：2

作者：

German, AC ^{[1
]}

Helps, CR ^{[1
]}

Harbour, DA ^{[1
]}

机构：

[1] Univ Bristol, Dept Vet Clin Sci, Bristol BS40 5DU, Avon, England

来源：

JOURNAL OF FELINE MEDICINE AND SURGERY | 2004年 / 6卷 / 02期

关键词：

D O I：

10.1016/j.jfms.2003.08.010

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

Feline infectious peritonitis (FIP) is a fatal disease of cats. Early attempts at vaccination have been unsuccessful, some even serving to exacerbate the disease through antibody-dependent enhancement. Replication-incompetent feline foamy virus (FFV) transducing vectors are being developed as potential vaccine agents, into which immunogenic fragments of feline coronavirus (FCoV) proteins will be inserted. To use a recombinant viral vector to express FCoV proteins, the agent chosen should be apathogenic and replication incompetent within the host following gene delivery. Spumaviruses confer several advantages over the more traditionally explored retrovirat vectors. Stable helper cell tine clones have been established by transfection of CRFK cells with FFV tas and assessed using beta-galactosidase assays, PCR, immunofluorescence and western blotting. The generation of infectious virions using these cell lines has been investigated using tas-deleted FFV vectors containing the enhanced green fluorescent protein (eGFP) cassette. (C) 2004 ESFM and AAFP. Published by Elsevier Ltd. All rights reserved.

引用

页码：119 / 124

页数：6

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