QUANTITATIVE ANALYSIS OF NOFRLOXACIN BY 1H NMR AND HPLC

被引：0
|
作者：
Frackowiak, Anita [1 ]
Kokot, Zenon J. [1 ]
机构：
[1] Poznan Univ Med Sci, Dept Inorgan & Analyt Chem, PL-60780 Poznan, Poland
来源：
ACTA POLONIAE PHARMACEUTICA | 2012年 / 69卷 / 04期
关键词：
fluoroquinolone; norfloxacin; quantitative H-1 NMR; HPLC; PERFORMANCE LIQUID-CHROMATOGRAPHY; MAGNETIC-RESONANCE-SPECTROSCOPY; NORFLOXACIN; FLUOROQUINOLONES; FLUORESCENCE; ASSAY; NMR;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
H-1 NMR and developed previously HPLC methods were applied to quantitative determination of norfloxacin in veterinary solution form for pigeon. Changes in concentration can lead to significant changes in the H-1 chemical shifts of non-exchangeable aromatic protons as a result of extensive self-association phenomena. This chemical shift variation of protons was analyzed and applied in the quantitative determination of norfloxacin. The method is simple, rapid, precise and accurate, and can be used for quality control of this drug.
引用
收藏
页码：597 / 601
页数：5
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