Implications of blood-brain barrier disruption in ALS

被引：33

作者：

Garbuzova-Davis, Svitlana ^{[1
,2
,3
]}

Saporta, Samuel ^{[3
]}

Sanberg, Paul R. ^{[2
,3
,4
]}

机构：

[1] Univ S Florida, Coll Med, Dept Neurosurg, Ctr Excellence Aging & Brain Repair, Tampa, FL 33612 USA

[2] Univ S Florida, Coll Med, Dept Mol Pharmacol & Physiol, Tampa, FL 33612 USA

[3] Univ S Florida, Coll Med, Dept Pathol & Cell Biol, Tampa, FL 33612 USA

[4] Univ S Florida, Coll Med, Dept Psychiat, Tampa, FL 33612 USA

来源：

AMYOTROPHIC LATERAL SCLEROSIS | 2008年 / 9卷 / 06期

关键词：

D O I：

10.1080/17482960802160990

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Our letter to the editor addresses important questions regarding the role of the blood-spinal cord barrier in amyotrophic lateral sclerosis. The novel finding of barrier dysfunction in ALS has implications for disease pathogenesis. This discussion should prove of widespread interest to researchers and may help in formulating various new therapeutic strategies to protect barrier function and thus extend functionality and lifespan in ALS patients.

引用

页码：375 / 376

页数：2

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