Semisynthesis of Peptoid-Protein Hybrids by Chemical Ligation at Serine

被引：32

作者：

Levine, Paul M. ^{[1
]}

Craven, Timothy W. ^{[2
]}

Bonneau, Richard ^{[2
,3
]}

Kirshenbaum, Kent ^{[1
]}

机构：

[1] NYU, Dept Chem, New York, NY 10003 USA

[2] NYU, Ctr Genom & Syst Biol, New York, NY 10003 USA

[3] NYU, Courant Inst Math Sci, Dept Comp Sci, New York, NY 10012 USA

来源：

ORGANIC LETTERS | 2014年 / 16卷 / 02期

基金：

美国国家科学基金会;

关键词：

PEPTIDE; THREONINE; SCAFFOLD; HORMONE; SITE;

D O I：

10.1021/ol4033978

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Chemical ligation protocols were explored for generating semisynthetic peptoid-protein hybrid architectures containing a native serine residue at the ligation site. Peptoid oligomers bearing C-terminal salicylaldehyde esters were synthesized and ligated to the N-terminus of the RNase S protein or the therapeutic hormone PTH(1-34) polypeptide. This technique will expand the repertoire of strategies to enable design of hybrid macromolecules with novel structures and functions not accessible to fully biosynthesized proteins.

引用

页码：512 / 515

页数：4

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