Low Risk of Occult Hepatitis B Infection among Vietnamese Blood Donors

被引：1

作者：

Tung, Tran Thanh ^{[1
,2
]}

Schmid, Juergen ^{[1
]}

Nghia, Vu Xuan ^{[3
]}

Cao, Le Chi ^{[1
,4
]}

Linh, Le Thi Kieu ^{[1
,2
]}

Rungsung, Ikrormi ^{[1
]}

Sy, Bui Tien ^{[1
,3
]}

My, Truong Nhat ^{[2
]}

The, Nguyen Trong ^{[2
,3
]}

Hoan, Nghiem Xuan ^{[2
,3
]}

Meyer, Christian G. ^{[1
,2
]}

Wedemeyer, Heiner ^{[5
,6
]}

Kremsner, Peter G. ^{[1
,7
]}

Toan, Nguyen Linh ^{[8
]}

Song, Le Huu ^{[2
,3
]}

Bock, C. -Thomas ^{[1
,9
]}

Velavan, Thirumalaisamy P. ^{[1
,2
]}

机构：

[1] Univ Tubingen, Inst Trop Med, D-72074 Tubingen, Germany

[2] Vietnamese German Ctr Med Res VG CARE, Hanoi 10000, Vietnam

[3] 108 Mil Cent Hosp, Hanoi 10000, Vietnam

[4] Hue Univ Med & Pharm HUMP, Dept Parasitol, Hue 52000, Vietnam

[5] Hannover Med Sch, Dept Gastroenterol Hepatol & Endocrinol, D-30623 Hannover, Germany

[6] German Ctr Infect Res, D-38104 Braunschweig, Germany

[7] Ctr Rech Med Lambarene, BP 242, Lambarene, Gabon

[8] Vietnam Mil Med Univ, Dept Pathophysiol, Hanoi 10000, Vietnam

[9] Robert Koch Inst, Dept Infect Dis, Div Viral Gastroenteritis & Hepatitis Pathogens &, D-13353 Berlin, Germany

来源：

PATHOGENS | 2022年 / 11卷 / 12期

关键词：

occult hepatitis B; hepatitis B virus; Vietnam; blood donors; hepatitis B surface antigen; VIRUS INFECTION; ANTI-HBC; MUTATIONS;

D O I：

10.3390/pathogens11121524

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Occult hepatitis B infection (OBI) is characterized by the presence of low levels of hepatitis B virus (HBV) DNA and undetectable HBsAg in the blood. The prevalence of OBI in blood donors in Asia ranges from 0.013% (China) to 10.9% (Laos), with no data available from Vietnam so far. We aimed to investigate the prevalence of OBI among Vietnamese blood donors. A total of 623 (114 women and 509 men) HBsAg-negative blood donors were screened for anti-HBc and anti-HBs by ELISA assays. In addition, DNA from sera was isolated and nested PCR was performed for the HBV surface gene (S); a fragment of the S gene was then sequenced in positive samples. The results revealed that 39% (n = 242) of blood donors were positive for anti-HBc, and 70% (n = 434) were positive for anti-HBs, with 36% (n = 223) being positive for both anti-HBc and anti-HBs. In addition, 3% of blood donors (n = 19) were positive for anti-HBc only, and 34% (n = 211) had only anti-HBs as serological marker. A total of 27% (n = 170) were seronegative for any marker. Two of the blood donors (0.3%) were OBI-positive and sequencing revealed that HBV sequences belonged to HBV genotype B, which is the predominant genotype in Vietnam.

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页数：10

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