Low Risk of Occult Hepatitis B Infection among Vietnamese Blood Donors

被引：1
|
作者：
Tung, Tran Thanh [1 ,2 ]
Schmid, Juergen [1 ]
Nghia, Vu Xuan [3 ]
Cao, Le Chi [1 ,4 ]
Linh, Le Thi Kieu [1 ,2 ]
Rungsung, Ikrormi [1 ]
Sy, Bui Tien [1 ,3 ]
My, Truong Nhat [2 ]
The, Nguyen Trong [2 ,3 ]
Hoan, Nghiem Xuan [2 ,3 ]
Meyer, Christian G. [1 ,2 ]
Wedemeyer, Heiner [5 ,6 ]
Kremsner, Peter G. [1 ,7 ]
Toan, Nguyen Linh [8 ]
Song, Le Huu [2 ,3 ]
Bock, C. -Thomas [1 ,9 ]
Velavan, Thirumalaisamy P. [1 ,2 ]
机构：
[1] Univ Tubingen, Inst Trop Med, D-72074 Tubingen, Germany
[2] Vietnamese German Ctr Med Res VG CARE, Hanoi 10000, Vietnam
[3] 108 Mil Cent Hosp, Hanoi 10000, Vietnam
[4] Hue Univ Med & Pharm HUMP, Dept Parasitol, Hue 52000, Vietnam
[5] Hannover Med Sch, Dept Gastroenterol Hepatol & Endocrinol, D-30623 Hannover, Germany
[6] German Ctr Infect Res, D-38104 Braunschweig, Germany
[7] Ctr Rech Med Lambarene, BP 242, Lambarene, Gabon
[8] Vietnam Mil Med Univ, Dept Pathophysiol, Hanoi 10000, Vietnam
[9] Robert Koch Inst, Dept Infect Dis, Div Viral Gastroenteritis & Hepatitis Pathogens &, D-13353 Berlin, Germany
来源：
PATHOGENS | 2022年 / 11卷 / 12期
关键词：
occult hepatitis B; hepatitis B virus; Vietnam; blood donors; hepatitis B surface antigen; VIRUS INFECTION; ANTI-HBC; MUTATIONS;
D O I：
10.3390/pathogens11121524
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Occult hepatitis B infection (OBI) is characterized by the presence of low levels of hepatitis B virus (HBV) DNA and undetectable HBsAg in the blood. The prevalence of OBI in blood donors in Asia ranges from 0.013% (China) to 10.9% (Laos), with no data available from Vietnam so far. We aimed to investigate the prevalence of OBI among Vietnamese blood donors. A total of 623 (114 women and 509 men) HBsAg-negative blood donors were screened for anti-HBc and anti-HBs by ELISA assays. In addition, DNA from sera was isolated and nested PCR was performed for the HBV surface gene (S); a fragment of the S gene was then sequenced in positive samples. The results revealed that 39% (n = 242) of blood donors were positive for anti-HBc, and 70% (n = 434) were positive for anti-HBs, with 36% (n = 223) being positive for both anti-HBc and anti-HBs. In addition, 3% of blood donors (n = 19) were positive for anti-HBc only, and 34% (n = 211) had only anti-HBs as serological marker. A total of 27% (n = 170) were seronegative for any marker. Two of the blood donors (0.3%) were OBI-positive and sequencing revealed that HBV sequences belonged to HBV genotype B, which is the predominant genotype in Vietnam.
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页数：10
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