New Topics in Vasopressin Receptors and Approach to Novel Drugs: Involvement of Vasopressin V1a and V1b Receptors in Nociceptive Responses and Morphine-Induced Effects

被引:19
|
作者
Honda, Kenji [1 ]
Takano, Yukio [1 ]
机构
[1] Fukuoka Univ, Fac Pharmaceut Sci, Dept Physiol & Pharmacol, Fukuoka 8140180, Japan
关键词
arginine vasopressin; V1a receptor; V1b receptor; nociceptive response; morphine-induced response; ANXIETY-RELATED BEHAVIOR; BETA-ENDORPHIN; ARGININE-VASOPRESSIN; SPINAL-CORD; RAT-BRAIN; INTRATHECAL VASOPRESSIN; PARAVENTRICULAR NUCLEUS; INDUCED ANTINOCICEPTION; PERIAQUEDUCTAL GRAY; INDUCED HYPOTHERMIA;
D O I
10.1254/jphs.08R30FM
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Arginine vasopressin (AVP) receptors have been classified into V1a, V1b, and V2 subtypes. Recent studies have demonstrated the involvement of AVP in anti-nociception and in morphine- induced anti-nociception. However, the roles of individual AVP-receptor subtypes have not been fully elucidated. Here, we have summarized the role of V1-receptor subtypes in behavioral responses to noxious stimuli and to morphine. In this review, we focus on studies using mice lacking the Via receptor (V1a(-/-) mice) and the V1b receptor (V1b(-/-) mice).
引用
收藏
页码:38 / 43
页数:6
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