Glass-based nanofluidic device for biomolecule preconcentration study

被引：10
|
作者：
Svarnas, P. [1 ]
Plecis, A. [1 ]
Nanteuil, C. [1 ]
Duong, D. [1 ]
David, C. [1 ]
Muller, M. [2 ]
Chen, Y. [1 ]
机构：
[1] CNRS, LPN, Lab Photon & Nanostruct, F-91460 Marcoussis, France
[2] GERAILP, GIP, CNRS, LALP,Lab Applicat Lasers Puissance, F-94114 Arcueil, France
来源：
EUROPEAN PHYSICAL JOURNAL-APPLIED PHYSICS | 2008年 / 44卷 / 03期
关键词：
D O I：
10.1051/epjap:2008176
中图分类号：
O59 [应用物理学];
学科分类号：
摘要：
The fabrication of a hybrid micro/nano-fluidic device to study electropreconcentration of biomolecules is presented. A nanoslit surrounded by glass is formed between two access microchannels and an "H" configuration bio-analysis system is developed. The optimized know-how for this biochip fabrication is transferred and the key steps are discussed. Fluorescence spatiotemporal profile in the preconcentration area is recorded and quantitatively analyzed. The reliability of the applied technology for studies of charged biomolecule transport phenomena across nanochannels is proven giving two examples for different preconcentration geometries.
引用
收藏
页码：245 / 253
页数：9
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