Loss of expression of the p16 gene is frequent in malignant skin tumors

被引：24
|
作者：
Chang, TG
Wang, JS
Chen, LW
Hsu, CY
Chang, HW
Chen, JS
Cho, CL
机构：
[1] VET GEN HOSP,DEPT PATHOL,KAOHSIUNG 813,TAIWAN
[2] VET GEN HOSP,DIV PLAST & RECONSTRUCT SURG,DEPT SURG,KAOHSIUNG 813,TAIWAN
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1997年 / 230卷 / 01期
关键词：
D O I：
10.1006/bbrc.1996.5891
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Expression of the pie gene from 30 malignant skin tumors has been surveyed by immunohistochemical assay. Gene point mutations were detected by DNA direct sequencing and the mRNA level of gene expression was measured by RT-PCR. A silent point mutation of the pie gene was found in only one patient. However, loss of expression of the pie gene was noticed in 23 of 29 samples (79.3%). Correlation between loss of expression of the pie gene and metastasis is significant (p = 0.0036). These findings suggest that loss of expression of the pie gene may play a critical role in tumor progression of malignant skin tumors. (C) 1997 Academic Press
引用
收藏
页码：85 / 88
页数：4
相关论文
共 50 条
  • [21] Expression of p16 in sinonasal malignant melanoma
    不详
    [J]. VIRCHOWS ARCHIV, 2005, 447 (02) : 133 - 133
  • [22] Expression of p16 in sinonasal malignant melanoma
    Alessandro Franchi
    Llucia Alos
    Nina Gale
    Daniela Massi
    Milena Paglierani
    Marco Santucci
    Nina Zidar
    Antonio Cardesa
    [J]. Virchows Archiv, 2006, 449 : 667 - 672
  • [23] Expression of p16 in sinonasal malignant melanoma
    Franchi, Alessandro
    Alos, Llucia
    Gale, Nina
    Massi, Daniela
    Paglierani, Milena
    Santucci, Marco
    Zidar, Nina
    Cardesa, Antonio
    [J]. VIRCHOWS ARCHIV, 2006, 449 (06) : 667 - 672
  • [24] Loss of expression of the p16 tumor suppressor gene is more frequent in advanced ovarian cancers lacking p53 mutations
    Havrilesky, LJ
    Alvarez, AA
    Whitaker, RS
    Marks, JR
    Berchuck, A
    [J]. GYNECOLOGIC ONCOLOGY, 2001, 83 (03) : 491 - 500
  • [25] Expression of P16 protein and Bcl-2 protein in malignant eyelid tumors
    Niu, YJ
    Zhou, ZY
    Liu, FL
    Wang, HY
    [J]. CHINESE MEDICAL JOURNAL, 2002, 115 (01) : 21 - 25
  • [26] LOSS OF P16(INK4) EXPRESSION IS FREQUENT IN HIGH-GRADE GLIOMAS
    NISHIKAWA, R
    FURNARI, FB
    LIN, H
    ARAP, W
    BERGER, MS
    CAVENEE, WK
    HUANG, HJS
    [J]. CANCER RESEARCH, 1995, 55 (09) : 1941 - 1945
  • [27] Frequent loss of p16 protein expression and high proliferative activity (Ki-67) in malignant melanoma from black Africans
    Vuhahula, E
    Straume, O
    Akslen, LA
    [J]. ANTICANCER RESEARCH, 2000, 20 (6C) : 4857 - +
  • [28] Loss of p16 Expression Differentiates Malignant Mesothelioma from Benign Mesothelial Proliferation
    Aydin, H.
    Chute, D.
    Yang, B.
    [J]. LABORATORY INVESTIGATION, 2011, 91 : 9A - 9A
  • [29] Loss of p16 Expression Differentiates Malignant Mesothelioma from Benign Mesothelial Proliferation
    Aydin, H.
    Chute, D.
    Yang, B.
    [J]. MODERN PATHOLOGY, 2011, 24 : 9A - 9A
  • [30] Frequent deletion and 5′ CpG island methylation of the p16 gene in primary malignant lymphoma of the brain
    Zhang, SJ
    Endo, S
    Ichikawa, T
    Washiyama, K
    Kumanishi, T
    [J]. CANCER RESEARCH, 1998, 58 (06) : 1231 - 1237
12345