Preliminary investigations on the synthesis and antitumor activity of 3(2H)-furanones

被引：23
|
作者：
Rappai, J. P. [1 ]
Raman, V. [1 ]
Unnikrishnan, P. A. [1 ]
Prathapan, S. [1 ]
Thomas, S. K. [2 ]
Paulose, C. S. [2 ]
机构：
[1] Cochin Univ Sci & Technol, Dept Appl Chem, Kochi 682022, Kerala, India
[2] Cochin Univ Sci & Technol, Dept Biotechnol, Kochi 682022, Kerala, India
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2009年 / 19卷 / 03期
关键词：
Furanone; Dibenzoylstyrene; Bromofuran; Antitumor agent; Furan oxidation; UNSATURATED 1,4-DIKETONES; INHIBITORS; DERIVATIVES; LACTONES;
D O I：
10.1016/j.bmcl.2008.12.030
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Two triaryl-3(2H)-furanones were synthesized and their antitumor activity was evaluated. These compounds inhibited the proliferation of DLA cell line in vitro. In vivo studies also showed that these compounds were active against tumor cell proliferation. (C) 2008 Elsevier Ltd. All rights reserved.
引用
收藏
页码：764 / 765
页数：2
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