DEVELOPMENT AND VALIDATION OF A UV SPECTROPHOTOMETRIC METHOD TO QUANTIFY CARVEDILOL

被引：7

作者：

Amarante Borba, Paola Aline ^{[1
]}

Riekes, Manoela Klueppel ^{[1
]}

Pereira, Rafael Nicolay ^{[1
]}

Stulzer, Hellen Karine ^{[1
]}

Dalla Vecchia, Debora ^{[2
]}

机构：

[1] Univ Fed Santa Catarina, Dept Ciencias Farmaceut, BR-88040900 Florianopolis, SC, Brazil

[2] Univ Estadual Ponta Grossa, Dept Ciencias Farmaceut, BR-84030900 Ponta Grossa, PR, Brazil

来源：

QUIMICA NOVA | 2013年 / 36卷 / 04期

关键词：

carvedilol; UV spectrophotometry; validation; QUANTIFICATION; HYPERTENSION; ASSAY; HPLC;

D O I：

10.1590/S0100-40422013000400017

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

This paper reports the development and validation of a new analytical method using UV spectrophotometry to quantify carvedilol (CRV) in hydrophilic matrices and raw material. This method was shown to be linear, accurate, precise, robust and to have adequate limits of quantification and detection (LQ and LD, respectively), allowing its use in the dissolution test of hydrophilic matrices. The content of CRV determined through this method was compared with two previously validated methods based on the reference techniques of High Performance Liquid Chromatography (HPLC) and Potentiometric Titrations (PT). ANOVA confirmed the equivalence of these methods, showing no significant differences.

引用

页码：582 / 586

页数：5

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