Synthesis of 1-substituted 5-acetyl (ethoxycarbonyl)-2,3-dihydropyrazolo-[3,4-b]pyridin-3-ones

被引：1

作者：

Lebed', P. S. ^{[1
]}

Mozgovaya, N. G. ^{[1
]}

Manoilenko, O. V. ^{[2
]}

Tolmachova, V. S. ^{[3
]}

Vovk, M. V. ^{[1
]}

机构：

[1] Natl Acad Sci Ukraine, Inst Organ Chem, UA-02094 Kiev, Ukraine

[2] Kyiv Taras Shevchenko Natl Univ, UA-01033 Kiev, Ukraine

[3] M Dragomanov Natl Pedag Univ, UA-01601 Kiev, Ukraine

来源：

CHEMISTRY OF HETEROCYCLIC COMPOUNDS | 2012年 / 48卷 / 07期

关键词：

5-acetyl-4-methyl-1,2-dihydropyrazolo[3,4-b]pyridin-3-ones; 1-substituted; 5-aminopyrazol-3-ones; ethyl 4-hydroxy-3-oxo-2,3-dihydropyrazolo[3,4-b]pyridine-5-carboxylate; ethoxymethylidene-beta-dicarbonyl compounds; PDE4; INHIBITORS; DERIVATIVES;

D O I：

10.1007/s10593-012-1099-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

1-Substituted 5-aminopyrazol-3-ones react selectively with ethoxymethylidene beta-dicarbonyl compounds (3-ethoxymethylidene-2,4-pentanedione, diethyl 2-ethoxymethylidenemalonate, and ethyl 2-ethoxy-methylideneacetoacetate) with the formation of dihydropyrazolylaminomethylidene beta-dicarbonyl derivatives, which undergo thermal intramolecular cyclization to 5-functionalized dihydro-pyrazolo[3,4-b]pyridin-3-ones.

引用

页码：1058 / 1063

页数：6

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