Wool-SO3H and nano-Fe3O4@wool as two green and natural-based renewable catalysts in one-pot isocyanide-based multicomponent reactions

Natural wool sulfonic acid (wool-SO3H) and wool-supported Fe3O4 nanoparticles (nano-Fe3O4@wool) with highly loaded Fe3O4 nanoparticles were simply synthesized and characterized by flame atomic absorption spectroscopy, X-ray diffraction, thermogravimetric analysis, and scanning electron microscopy. The successful synthesis of 3,4-dihydroquinoxalin-2-amine, 1,6-dihydropyrazine-2,3-dicarbonitrile, (cyanophenylamino)acetamide, tetrahydro-1H-1,5-benzodiazepine-2-carboxamide, and 4,5,6,7-tetrahydro-1H-1,4-diazepine-5-carboxamide derivatives shows that wool-SO3H and Fe3O4@wool nanocomposite have high catalytic activity and can be repetitively used as two biodegradable catalysts.