Interception of quorum sensing in Staphylococcus aureus:: a new niche for peptidomimetics

被引：24
|
作者：
Gorske, BC [1 ]
Blackwell, HE [1 ]
机构：
[1] Univ Wisconsin, Dept Chem, Madison, WI 53706 USA
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2006年 / 4卷 / 08期
关键词：
D O I：
10.1039/b517681f
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Pathogenesis in Staphylococcus aureus is dependent on local cell density and is regulated in part by small macrocyclic peptides. Natural and artificial peptide inhibitors of this quorum sensing response have been synthesized and evaluated in structure - activity relationship studies. These investigations have illuminated the quorum sensing mechanism and set the stage for the design of biostable, peptidomimetic inhibitors that could be developed ultimately as therapeutics.
引用
收藏
页码：1441 / 1445
页数：5
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