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Yonsei Univ, Chem Genom Natl Res Lab, Translat Res Ctr Prot Funct Control, Dept Biotechnol,Coll Life Sci & Biotechnol, Seoul 120749, South Korea Yonsei Univ, Chem Genom Natl Res Lab, Translat Res Ctr Prot Funct Control, Dept Biotechnol,Coll Life Sci & Biotechnol, Seoul 120749, South Korea