Deletion mapping of potential tumor suppressor genes on chromosome 1p34.2-pter in sporadic colorectal carcinoma

被引：0
|
作者：
Finke, LH [1 ]
Praml, C [1 ]
Herfarth, C [1 ]
Schwab, M [1 ]
Amler, L [1 ]
Schlag, PM [1 ]
机构：
[1] FREE UNIV BERLIN,KLINIKUM RUDOLF VIRCHOW,ROBERT ROSSLE KLIN,D-13122 BERLIN,GERMANY
来源：
LANGENBECKS ARCHIV FUR CHIRURGIE | 1996年
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中图分类号：
R61 [外科手术学];
学科分类号：
摘要：
Tissue specimen of 37 colorectal cancers were analyzed on the prevalence of LOH by PCR and hybridization of 37 microsatellite markers located on chromosome 1p. LOH was observed in 31 of 37 of this tumors. Three regions showing maximum frequence of mutations were identified. It was concluded that this regions may harbour tumor suppressor genes relevant in colorectal cancer. The homology of the affected region on human chromosome 1 with the Mom-1 modifier gene locus of mice is discussed.
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页码：429 / 433
页数：5
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