Deletion mapping of potential tumor suppressor genes on chromosome 1p34.2-pter in sporadic colorectal carcinoma

被引：0
|
作者：
Finke, LH [1 ]
Praml, C [1 ]
Herfarth, C [1 ]
Schwab, M [1 ]
Amler, L [1 ]
Schlag, PM [1 ]
机构：
[1] FREE UNIV BERLIN,KLINIKUM RUDOLF VIRCHOW,ROBERT ROSSLE KLIN,D-13122 BERLIN,GERMANY
来源：
LANGENBECKS ARCHIV FUR CHIRURGIE | 1996年
关键词：
D O I：
暂无
中图分类号：
R61 [外科手术学];
学科分类号：
摘要：
Tissue specimen of 37 colorectal cancers were analyzed on the prevalence of LOH by PCR and hybridization of 37 microsatellite markers located on chromosome 1p. LOH was observed in 31 of 37 of this tumors. Three regions showing maximum frequence of mutations were identified. It was concluded that this regions may harbour tumor suppressor genes relevant in colorectal cancer. The homology of the affected region on human chromosome 1 with the Mom-1 modifier gene locus of mice is discussed.
引用
收藏
页码：429 / 433
页数：5
相关论文
共 50 条
  • [1] Are there tumor suppressor genes on chromosome 4p in sporadic colorectal carcinoma?
    Hai-Tao Zheng
    World Journal of Gastroenterology, 2008, (01) : 90 - 94
  • [2] Are there tumor suppressor genes on chromosome 4p in sporadic colorectal carcinoma?
    Zheng, Hai-Tao
    Jiang, Li-Xin
    Lv, Zhong-Chuan
    Li, Da-Peng
    Zhou, Chong-Zhi
    Gao, Jian-Jun
    He, Lin
    Peng, Zhi-Hai
    WORLD JOURNAL OF GASTROENTEROLOGY, 2008, 14 (01) : 90 - 94
  • [3] DELETION MAPPING DEFINES DIFFERENT REGIONS IN 1P34.2-PTER THAT MAY HARBOR GENETIC INFORMATION RELATED TO HUMAN COLORECTAL-CANCER
    PRAML, C
    FINKE, LH
    HERFARTH, C
    SCHLAG, P
    SCHWAB, M
    AMLER, L
    ONCOGENE, 1995, 11 (07) : 1357 - 1362
  • [4] Deletion mapping of two potential chromosome 14 tumor suppressor gene loci in ovarian carcinoma
    Bandera, CA
    Takahashi, H
    Behbakht, K
    Liu, PC
    LiVolsi, VA
    Benjamin, I
    Morgan, MA
    King, SA
    Rubin, SC
    Boyd, J
    CANCER RESEARCH, 1997, 57 (03) : 513 - 515
  • [5] DELETION MAPPING OF A TUMOR-SUPPRESSOR GENE ON CHROMOSOME-8 IN COLORECTAL AND LUNG-CARCINOMA
    WESTBROOK, CA
    YAREMKO, L
    KELEMAN, PR
    LEACH, S
    MINNA, JD
    WASLYSHYN, ML
    MICHELASSI, F
    OLOPADE, F
    WOOD, S
    CYTOGENETICS AND CELL GENETICS, 1993, 64 (3-4): : 146 - 146
  • [6] 1p-alterations in human cancer: Deletions in 1p34.2-pter in colorectal cancer and a reciprocal translocation (1;15)(36.2;q24) in a neuroblastoma cell line define putative loci for tumor supressor genes
    Praml, C
    Corvi, R
    Finke, LH
    Savelyeva, L
    Paslier, D
    Schwab, M
    Amler, LC
    CYTOGENETICS AND CELL GENETICS, 1996, 72 (2-3): : 150 - 150
  • [7] Chromosome 6 deletion and candidate tumor suppressor genes in adenoid cystic carcinoma
    Rutherford, Sue
    Yu, Yongtao
    Rumpel, Craig A.
    Frierson, Henry F., Jr.
    Moskaluk, Christopher A.
    CANCER LETTERS, 2006, 236 (02) : 309 - 317
  • [8] Deletion mapping of the tumor suppressor locus involved in colorectal cancer on chromosome band 8p21
    Lerebours, F
    Olschwang, S
    Thuille, B
    Schmitz, A
    Fouchet, P
    Laurent-Puig, P
    Boman, F
    Fléjou, JF
    Monges, G
    Pavaf, F
    Bedossa, P
    Sabourin, JC
    Salmon, RJ
    Parc, R
    Thomas, G
    GENES CHROMOSOMES & CANCER, 1999, 25 (02): : 147 - 153
  • [9] Investigation of tumor suppressor genes apart from VHL on 3p by deletion mapping in sporadic clear cell renal cell carcinoma (cRCC)
    Singh, Rashmi Bhat
    Kadam, Pratibha S. Amare
    UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS, 2013, 31 (07) : 1333 - 1342
  • [10] EVIDENCE FOR THE PRESENCE OF 2 TUMOR SUPPRESSOR GENES ON CHROMOSOME-8P FOR COLORECTAL-CARCINOMA
    FUJIWARA, Y
    EMI, M
    OHATA, H
    KATO, Y
    NAKAJIMA, T
    MORI, T
    NAKAMURA, Y
    CANCER RESEARCH, 1993, 53 (05) : 1172 - 1174
12345