Bioorthogonal Catalytic Activation of Platinum and Ruthenium Anticancer Complexes by FAD and Flavoproteins

被引：55

作者：

Alonso-de Castro, Silvia ^{[2
]}

Cortajarena, Aitziber L. ^{[2
,3
]}

Lopez-Gallego, Fernando ^{[2
,4
]}

Salassa, Luca ^{[1
,3
]}

机构：

[1] Donostia Int Phys Ctr, Paseo Manuel de Lardizabal 4, Donostia San Sebastian 20018, Spain

[2] CIC biomaGUNE, Paseo Miramon 182, Donostia San Sebastian 20014, Spain

[3] Basque Fdn Sci, Ikerbasque, Bilbao 48011, Spain

[4] ARAID Fdn, Zaragoza, Spain

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2018年 / 57卷 / 12期

基金：

欧洲研究理事会;

关键词：

bioorthogonal chemistry; flavoproteins; metal-based prodrugs; photocatalysis; photochemotherapy; DNA-BINDING; OXYGEN; AGENTS; CELLS; GENERATION; REDUCTION; CHEMISTRY; MECHANISM; DELIVERY;

D O I：

10.1002/anie.201800288

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Recent advances in bioorthogonal catalysis promise to deliver new chemical tools for performing chemoselective transformations in complex biological environments. Herein, we report how FAD (flavin adenine dinucleotide), FMN (flavin mononucleotide), and four flavoproteins act as unconventional photocatalysts capable of converting Pt-IV and Ru-II complexes into potentially toxic Pt-II or Ru-II-OH2 species. In the presence of electron donors and low doses of visible light, the flavoproteins mini singlet oxygen generator (miniSOG) and NADH oxidase (NOX) catalytically activate Pt-IV prodrugs with bioorthogonal selectivity. In the presence of NADH, NOX catalyzes Pt-IV activation in the dark as well, indicating for the first time that flavoenzymes may contribute to initiating the activity of Pt-IV chemotherapeutic agents.

引用

页码：3143 / 3147

页数：5

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