Streptococcus pyogenes isolates with high-level macrolide resistance and reduced susceptibility to telithromycin associated with 23S rRNA mutations

被引：13
|
作者：
Farrell, DJ
Shackcloth, J
Barbadora, KA
Green, MD
机构：
[1] GR Micro Ltd, Med & Mol Microbiol, London NW1 3ER, England
[2] Univ Pittsburgh, Sch Med, Div Pediat Allergy Immunol & Infect Dis, Pittsburgh, PA 15260 USA
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2006年 / 50卷 / 02期
基金：
英国惠康基金;
关键词：
D O I：
10.1128/AAC.50.2.817-818.2006
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Seven high-level macrolide-resistant Streptococcus pyogenes isolates had reduced activity to telithromycin but were negative for methylation and efflux genes. All were of the constitutive phenotype, were clonally related (emm type 12 and MLST type 36), and had identical dual mutations (A2058G and U2166C) in domain V of 23S rRNA.
引用
收藏
页码：817 / 818
页数：2
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