Comparison of analytical techniques for the identification of bioactive compounds from natural products

被引：105

作者：

Ciesla, Lukasz ^{[1
,2
]}

Moaddel, Ruin ^{[1
]}

机构：

[1] NIA, Lab Clin Invest, Biomed Res Ctr, NIH, 8C232,251 Bayview Blvd, Baltimore, MD 21224 USA

[2] Med Univ Lublin, Dept Inorgan Chem, Chodzki 4A, PL-20093 Lublin, Poland

来源：

NATURAL PRODUCT REPORTS | 2016年 / 33卷 / 10期

关键词：

MEMBRANE AFFINITY-CHROMATOGRAPHY; COATED MAGNETIC BEADS; PERFORMANCE LIQUID-CHROMATOGRAPHY; OPEN-TUBULAR COLUMN; ULTRAFILTRATION-MASS-SPECTROMETRY; NICOTINIC ACETYLCHOLINE-RECEPTORS; GINGER ZINGIBER-OFFICINALE; IMMOBILIZED P-GLYCOPROTEIN; SOLID-PHASE EXTRACTION; HPLC-SPE-NMR;

D O I：

10.1039/c6np00016a

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Natural product extracts are a rich source of bioactive compounds. As a result, the screening of natural products for the identification of novel biologically active metabolites has been an essential part of several drug discovery programs. It is estimated that more than 70% of all drugs approved from 1981 and 2006, were either derived from or structurally similar to nature based compounds indicating the necessity for the development of a rapid method for the identification of novel compounds from plant extracts. The screening of biological matrices for the identification of novel modulators is nevertheless still challenging. In this review we discuss current techniques in phytochemical analysis and the identification of biologically active components.

引用

页码：1131 / 1145

页数：15

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