Listeria-based HPV-16 E7 vaccines limit autochthonous tumor growth in a transgenic mouse model for HPV-16 transformed tumors

被引：72
|
作者：
Sewell, Duane A. [1 ]
Pan, Zhen Kun [2 ]
Paterson, Yvonne [2 ]
机构：
[1] Univ Penn, Sch Med, Dept Otorhinolaryngol Head & Neck Surg, Philadelphia, PA 19104 USA
[2] Univ Penn, Sch Med, Dept Microbiol, Philadelphia, PA 19104 USA
来源：
VACCINE | 2008年 / 26卷 / 41期
基金：
美国国家卫生研究院;
关键词：
Cancer vaccines; Listeria; HPV-16;
D O I：
10.1016/j.vaccine.2008.07.036
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
We have shown that Listeria-based cancer vaccines inhibit the growth of transplanted tumors in a transgenic mouse model of immune tolerance where HPV-16 E7 is expressed in the thyroid gland. In this study we determine whether these vaccines are able to inhibit autochthonous tumor growth in this animal model. Mice treated with Listeria vaccines expressing E7 had significantly smaller thyroid tumors than did mice treated with controls and possessed higher numbers of antigen-specific CD8(+) T cells within the spleens, tumors, and peripheral blood. This study shows that Listeria-based vaccines are able to slow autochthonous tumor growth and break immunological tolerance. (C) 2008 Elsevier Ltd. All rights reserved.
引用
收藏
页码：5315 / 5320
页数：6
相关论文
共 50 条
  • [21] Expression of interstitial collagenase and its endogenous regulators in immortalized and transformed by HPV-16 E7 gene fibroblasts
    O. S. Ryzhakova
    T. A. Gureeva
    V. A. Zhurbitskaya
    N. I. Solovyeva
    Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry, 2007, 1 (4) : 342 - 347
  • [22] Identification of RNA aptamers that internalize into HPV-16 E6/E7 transformed tonsillar epithelial cells
    Gourronc, Francoise A.
    Rockey, William M.
    Thiel, William H.
    Giangrande, Paloma H.
    Klingelhutz, Aloysius J.
    VIROLOGY, 2013, 446 (1-2) : 325 - 333
  • [23] Anti-E6.5, anti-E6.12 (booth recognize HPV-16 E6 protein), and anti-E7 (recognizes HPV-16 E7 protein)
    Ertl, HCJ
    HYBRIDOMA, 2001, 20 (04): : 283 - 283
  • [24] DNA vaccines against HPV-16 E7-expressing tumour cells
    De Marco, F
    Hallez, S
    Brulet, JM
    Gesché, F
    Marzano, P
    Flamini, S
    Marcante, ML
    Venuti, A
    ANTICANCER RESEARCH, 2003, 23 (2B) : 1449 - 1454
  • [25] The HPV-16 E7 oncoprotein binds Skip and suppresses its transcriptional activity
    Tulasiram Prathapam
    Christian Kühne
    Lawrence Banks
    Oncogene, 2001, 20 : 7677 - 7685
  • [26] CHARACTERIZATION OF FUNCTIONAL HPV-16 E7 PROTEIN PRODUCED IN ESCHERICHIA-COLI
    PATRICK, DR
    ZHANG, K
    DEFEOJONES, D
    VUOCOLO, GR
    MAIGETTER, RZ
    SARDANA, MK
    OLIFF, A
    HEIMBROOK, DC
    JOURNAL OF BIOLOGICAL CHEMISTRY, 1992, 267 (10) : 6910 - 6915
  • [27] Nuclear import of HPV-16 E7 occurs via an active transport mechanism
    Cid-Arregui, A
    García, G
    Jacjinovic, M
    zur Hausen, H
    EUROPEAN JOURNAL OF CELL BIOLOGY, 2005, 84 : 46 - 46
  • [28] IDENTIFICATION OF HPV-16 E7 PEPTIDES THAT ARE POTENT ANTAGONISTS OF E7 BINDING TO THE RETINOBLASTOMA SUPPRESSOR PROTEIN
    JONES, RE
    WEGRZYN, RJ
    PATRICK, DR
    BALISHIN, NL
    VUOCOLO, GA
    RIEMEN, MW
    DEFEOJONES, D
    GARSKY, VM
    HEIMBROOK, DC
    OLIFF, A
    JOURNAL OF BIOLOGICAL CHEMISTRY, 1990, 265 (22) : 12782 - 12785
  • [29] THE HPV-16 E7 ORF ENCODES A PROTEIN WITH TRANSFORMATION AND TRANSCRIPTIONAL TRANSACTIVATION FUNCTIONS
    PHELPS, WC
    YEE, CL
    MUNGER, K
    HOWLEY, PM
    FASEB JOURNAL, 1988, 2 (04): : A804 - A804
  • [30] The HPV-16 E7 oncoprotein binds Skip and suppresses its transcriptional activity
    Prathapam, T
    Kühne, C
    Banks, L
    ONCOGENE, 2001, 20 (52) : 7677 - 7685
12345