Micromechanical properties of human trabecular bone: A hierarchical investigation using nanoindentation

被引：42

作者：

Norman, Jonathan ^{[1
,2
,3
]}

Shapter, Joe G. ^{[3
]}

Short, Ken ^{[4
]}

Smith, Lachlan J. ^{[1
,2
,5
]}

Fazzalari, Nicola L. ^{[1
,2
,5
]}

机构：

[1] Inst Med & Vet Sci, Div Tissue Pathol, Bone & Joint Res Lab, Adelaide, SA 5000, Australia

[2] Hanson Inst, Adelaide, SA, Australia

[3] Flinders Univ S Australia, Sch Chem Phys & Earth Sci, Adelaide, SA, Australia

[4] Australian Nucl Sci & Technol Org, Div Engn & Mat Sci, Menai, NSW 2234, Australia

[5] Univ Adelaide, Sch Med Sci, Discipline Pathol, Adelaide, SA 5005, Australia

来源：

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A | 2008年 / 87A卷 / 01期

基金：

英国医学研究理事会;

关键词：

trabecular bone; structural hierarchy; micromechanical properties; nanoindentation;

D O I：

10.1002/jbm.a.31766

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

The ability to assess the risk of fracture, evaluate new therapies, predict implant success and assess the influence of bone remodeling disorders requires specific measurement of local bone micromechanical properties. Nanoindentation is an established tool for assessing the micromechanical properties of hard biological tissues. In this study, elastic modulus and hardness were quantified using nanoindentation for human trabccular bone from the intertrochanteric region of the proximal femur. These properties were demonstrated to be heterogeneous and highly correlated at the intraspicule, interspicule, and interspecimen levels. The results of this study have important implications for current understanding of structure-function relationships throughout the trabecular bone structural hierarchy. (C) 2007 Wiley Periodicals, Inc.

引用

页码：196 / 202

页数：7

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