Antibacterial and cytocompatible coatings based on poly(adipic anhydride) for a Ti alloy surface<bold> </bold>

被引:23
|
作者
Lesniak-Ziolkowska, Katarzyna [1 ]
Smiga-Matuszowicz, Monika [2 ]
Blacha-Grzechnik, Agata [2 ]
Student, Sebastian [3 ,4 ]
Brzychczy-Wloch, Monika [5 ]
Krok-Borkowicz, Malgorzata [6 ]
Pamula, Elzbieta [6 ]
Simka, Wojciech [1 ]
Kazek-Kesik, Alicja [1 ,3 ]
机构
[1] Silesian Tech Univ, Fac Chem, B Krzywoustego St 6, PL-44100 Gliwice, Poland
[2] Silesian Tech Univ, Fac Chem, M Strzody 9 St, PL-44100 Gliwice, Poland
[3] Silesian Tech Univ, Biotechnol Ctr, B Krzywoustego 8 St, PL-44100 Gliwice, Poland
[4] Silesian Tech Univ, Fac Automat Control Elect & Comp Sci, Dept Syst Biol & Engn, Akad 16, PL-44100 Gliwice, Poland
[5] Jagiellonian Univ, Dept Microbiol, Med Coll, Czysta 18 St, PL-31121 Krakow, Poland
[6] AGH Univ Sci & Technol, Fac Mat Sci & Ceram, Mickiewicza Av 30, PL-30059 Krakow, Poland
关键词
Titanium alloy; poly(adipic anhydride); Antibacterial coatings; Cytocompatible; Dental implants<bold>; </bold>; PLASMA ELECTROLYTIC OXIDATION; PLASTIC-DEFORMATION; DELIVERY-SYSTEM; IN-VITRO; TITANIUM; OSTEOMYELITIS; MICROSTRUCTURE; DEGRADATION; CARBONATE); DESIGN;
D O I
10.1016/j.bioactmat.2020.04.020
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
This paper describes a formation of hybrid coatings on a Ti-2Ta-3Zr-36Nb surface. This is accomplished by plasma electrolytic oxidation and a dip-coating technique with poly(adipic anhydride) ((C6H8O3)n) that is loaded with drugs: amoxicillin (C16H19N3O5S), cefazolin (C14H14N8O4S3) or vancomycin (C66H75Cl2N9O24 center dot xHCl). The characteristic microstructure of the polymer was evaluated using scanning electron microscopy and confocal microscopy. Depending on the surface treatment, the surface roughness varied (between 1.53 mu m and 2.06 mu m), and the wettability was change with the over of time. X-ray photoelectron spectroscopy analysis showed that the oxide layer did not affect the polymer layer or loaded drugs. However, the drugs lose their stability in a phosphate-buffered saline solution after 6.5 h of exposure, and its decrease was greater than 7% (HPLC analysis). The stability, drug release and concentration of the drug loaded into the material were precisely analyzed by high-performance liquid chromatography. The results correlated with the degradation of the polymer in which the addition of drugs caused the percent of degraded polymer to be between 35.5% and 49.4% after 1 h of material immersion, depending on the mass of the loaded drug and various biological responses that were obtained. However, all of the coatings were cytocompatible with MG-63 osteoblast-like cells. The drug concentrations released from the coatings were sufficient to inhibit adhesion of reference and clinical bacterial strains (S. aureus). The coatings with amoxicillin showed the best results in the bacterial inhibition zone, whereas coatings with cefazolin inhibited adhesion of the above bacteria on the surface.<bold> </bold>
引用
收藏
页码:709 / 720
页数:12
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