Construction of a graphene/polypyrrole composite electrode as an electrochemically controlled release system

被引：17
|
作者：
Zhu, Mo [1 ,2 ]
Hao, Ying [2 ]
Ma, Xun [2 ]
Feng, Lin [2 ]
Zhai, Yuanxin [2 ]
Ding, Yaping [1 ]
Cheng, Guosheng [2 ]
机构：
[1] Shanghai Univ, Dept Chem, Shanghai 200444, Peoples R China
[2] Chinese Acad Sci, Suzhou Inst Nanotech & Nanobion, CAS Key Lab Nanobio Interface, Suzhou 215123, Jiangsu, Peoples R China
来源：
RSC ADVANCES | 2019年 / 9卷 / 22期
基金：
中国国家自然科学基金;
关键词：
DRUG-DELIVERY; POLYPYRROLE NANOPARTICLES; BIOMEDICAL APPLICATIONS; GRAPHENE; NANOCOMPOSITES; POLYMERS; FILMS;
D O I：
10.1039/c9ra00800d
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A new class of stimuli responsive drug delivery systems is emerging to establish new paradigms for enhancing therapeutic efficacy. To date, most electro-responsive systems rely on noble metal electrodes that likely cause the limitations for implantation applications. Herein, a graphene/polypyrrole composite electrode (GN-PPy-FL) was fabricated based on two-dimensional (2D) graphene (GN) film and conductive and biocompatible polypyrrole (PPy) nanoparticles loaded with a negative drug model of fluorescein sodium (FL) via chemical oxidation polymerization. The conductive composite electrode was utilized as a drug carrier to realize the electrically controlled release of the FL. The release rate from conductive nanoparticles can be controlled by the applied voltages. The study provides a multi-stimuli responsive drug release system, demonstrating the potential applications of the controlled release of various drugs, peptides or proteins.
引用
收藏
页码：12667 / 12674
页数：8
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