Growth hormone and insulin-like growth factor-I axis in type 1 diabetes

被引：19
|
作者：
Nambam, Bimota [1 ]
Schatz, Desmond [2 ]
机构：
[1] Louisiana State Univ Hlth, Pediat Endocrinol, Shreveport, LA USA
[2] Univ Florida, Pediat Endocrinol, Gainesville, FL USA
来源：
GROWTH HORMONE & IGF RESEARCH | 2018年 / 38卷
关键词：
Type; 1; diabetes; Growth hormone; Insulin like growth factor-I; Portal hypoinsulinization; Height; FACTOR-BINDING PROTEIN-3; BETA-CELL FUNCTION; IGF-I; GLYCEMIC CONTROL; FACTOR SYSTEM; FOLLOW-UP; CHILDREN; MELLITUS; ADOLESCENTS; HEIGHT;
D O I：
10.1016/j.ghir.2017.12.005
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The precise mechanisms relating type 1 diabetes (T1D) and poor glycemic control to the axis of growth hormone (GH), insulin like growth factor-I (IGF-I), and IGF binding protein-3 (IGFBP-3) remain to be definitively determined. GH resistance with low IGF-I as is frequently seen in patients with T1D is often related to portal hypoinsulization, and lack of upregulation of GH receptors. There are conflicting reports of the effect of a dysregulated GH/IGF-I axis on height in children and adolescents with T1D, as well as on chronic complications. This brief review discusses some of the interactions between the GH/IGF-I axis and T1D pathology, and vice versa.
引用
收藏
页码：49 / 52
页数：4
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