Phenolics from Leontopodium leontopodioides inhibiting nitric oxide production

被引：34

作者：

Li, Xin ^{[1
]}

Luo, Jian-Guang ^{[1
]}

Wang, Xiao-Bing ^{[1
]}

Luo, Jun ^{[1
]}

Wang, Jun-Song ^{[1
]}

Kong, Ling-Yi ^{[1
]}

机构：

[1] China Pharmaceut Univ, Dept Nat Med Chem, State Key Lab Nat Med, Nanjing 210009, Peoples R China

来源：

FITOTERAPIA | 2012年 / 83卷 / 05期

基金：

中国国家自然科学基金;

关键词：

Leontopodium leontopodioides; Neolignan; Benzofuran derivative; Nitric oxide; RAW264.7; macrophages; DERIVATIVES;

D O I：

10.1016/j.fitote.2012.03.020

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Two new compounds, a neolignan (1), and a benzofuran derivative (2), along with 6 known compounds (3-8), were isolated from the aerial parts of Leontopodium leontopodioides. The structures of the new compounds were elucidated as (7R,8S)-3,5'-dimethoxy-4',7-epoxy-8,3'-neolignane-5,9,9'-triol (1) and (2R)-12-hydoxy-4-methoxy-tremeton (2) on the basis of their spectroscopic data, respectively. All of the isolates were evaluated for their effects on the inhibition of nitric oxide (NO) production in lipopolysaccharide-activated RAW264.7 macrophages and compounds 1 and 8 exhibited inhibitory activity with IC50 values of 35.80 and 24.41 mu M respectively. (C) 2012 Elsevier B.V. All rights reserved.

引用

页码：883 / 887

页数：5

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