Pregnancy-onset habitual snoring, gestational hypertension, and preeclampsia: prospective cohort study

被引:125
|
作者
O'Brien, Louise M. [1 ,2 ]
Bullough, Alexandra S. [3 ]
Owusu, Jocelynn T. [1 ]
Tremblay, Kimberley A. [1 ]
Brincat, Cynthia A. [4 ]
Chames, Mark C. [4 ]
Kalbfleisch, John D. [5 ]
Chervin, Ronald D. [1 ]
机构
[1] Univ Michigan, Sch Med, Sleep Disorders Ctr, Dept Neurol, Ann Arbor, MI 48109 USA
[2] Univ Michigan, Sch Med, Dept Oral & Maxillofacial Surg, Ann Arbor, MI 48109 USA
[3] Univ Michigan, Sch Med, Dept Anesthesiol, Ann Arbor, MI 48109 USA
[4] Univ Michigan, Sch Med, Dept Obstet & Gynecol, Ann Arbor, MI 48109 USA
[5] Univ Michigan, Sch Med, Dept Biostat, Ann Arbor, MI 48109 USA
关键词
gestational diabetes; gestational hypertension; preeclampsia; pregnancy; snoring; SLEEP-APNEA; RISK-FACTOR; ASSOCIATION; SYMPTOMS; VALIDITY; OUTCOMES; DISEASE; WOMEN; MEN;
D O I
10.1016/j.ajog.2012.08.034
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
OBJECTIVE: This study aimed to prospectively examine the impact of chronic vs pregnancy-onset habitual snoring on gestational hypertension, preeclampsia, and gestational diabetes. STUDY DESIGN: Third-trimester pregnant women were recruited from a large, tertiary medical center from March 2007 through December 2010 and screened for the presence and duration of habitual snoring, as a known marker for sleep-disordered breathing. Clinical diagnoses of gestational hypertension, preeclampsia, and gestational diabetes were obtained. RESULTS: Of 1719 pregnant women, 34% reported snoring, with 25% reporting pregnancy-onset snoring. After adjusting for confounders, pregnancy-onset, but not chronic, snoring was independently associated with gestational hypertension (odds ratio, 2.36; 95% confidence interval, 1.48-3.77; P < .001) and preeclampsia (odds ratio, 1.59; 95% confidence interval, 1.06-2.37; P = .024) but not gestational diabetes. CONCLUSION: New-onset snoring during pregnancy is a strong risk factor for gestational hypertension and preeclampsia. In view of the significant morbidity and health care costs associated with hypertensive diseases of pregnancy, simple screening of pregnant women may have clinical utility.
引用
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页数:9
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