Effects of low-dose alfentanil administration on central respiratory drive and respiratory pattern in spontaneously breathing ASA 1 patients

The aim of this study was to assess the short-term effects of the administration of low doses of alfentanil on respiratory drive and respiratory pattern. We studied 17 ASA I patients scheduled for minor surgery or endoscopic procedures. During spontaneous ventilation, Respiratory Rate, Tidal Volume, Total Respiratory Cycle, Inspiratory and Expiratory Time, Mean Inspiratory Flow, P0.1, SaO2 and EtCO2 were all measured. The inspired oxygen concentration was 21% and measurements were made at baseline, 5 min (T1), 10 min (T2) and 15 min (T3) following an intravenous bolus injection 10 mug.kg(-1) alfentanil. The administration of alfentanil produced a significant (p < 0.05) reduction in SaO2 , minute volume and P0.1. In ASA I spontaneously breathing patients, the pre-operative administration of low doses of alfentanil can initially reduce the respiratory centre activity leading to a reduction in minute volume and SaO2 . We therefore recommend careful monitoring of cardio-respiratory function in ASA I patients, following the administration of alfentanil.