Dual inhibition of HCV and HIV by ring-expanded nucleosides containing the 5: 7-fused imidazo[4,5-e][1,3] diazepine ring system. In vitro results and implications

被引：17

作者：

Zhang, Ning ^{[1
]}

Zhang, Peng ^{[1
]}

Baier, Andrea ^{[2
]}

Cova, Lucyna ^{[3
]}

Hosmane, Ramachandra S. ^{[1
]}

机构：

[1] Univ Maryland Baltimore Cty, Dept Chem & Biochem, Lab Drug Design & Synth, Baltimore, MD 21250 USA

[2] John Paul II Catholic Univ Lublin, Dept Mol Biol, Lublin, Poland

[3] INSERM, U871, F-69003 Lyon 03, France

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2014年 / 24卷 / 04期

基金：

美国国家卫生研究院;

关键词：

Ring-expanded nucleosides; Imidazo[4,5-e][1,3] diazepines; Organic synthesis; Antiviral compounds; In vitro screening; Hepatitis C virus (HCV); Human immunodeficiency virus (HIV); Dual inhibitors of HCV and HIV; Inhibition of HCV NTPase/helicase; Inhibition of RNA helicase DDX3; HEPATITIS-C VIRUS; HUMAN-IMMUNODEFICIENCY-VIRUS; WEST-NILE VIRUS; INFECTED PATIENTS; HIV/HCV COINFECTION; FAT NUCLEOSIDE; LIVER FIBROSIS; RNA HELICASE; INTERFERON; UPDATE;

D O I：

10.1016/j.bmcl.2013.12.121

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Examples of ring-expanded nucleosides (RENs), represented by general structures 1 and 2, exhibited dual anti-HCV and anti-HIV activities in both cell culture systems and the respective target enzyme assays, including HCV NTPase/helicase and human RNA helicase DDX3. Since HCV is a leading co-infection in late stage HIV AIDS patients, often leading to liver cirrhosis and death, the observed dual inhibition of HCV and HIV by the target nucleoside analogues has potentially beneficial implications in treating HIV patients infected with HCV. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：1154 / 1157

页数：4

共 41 条

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HOSMANE, RS
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[13] Synthesis of a novel ring-expanded ("fat") nucleotide analogue of phosphonomethoxyethylguanine (PMEG) containing the imidazo[4,5-e][1,3]diazepine ring system
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JOURNAL OF HETEROCYCLIC CHEMISTRY, 2001, 38 (06) : 1313 - 1315
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Hosmane, RS
NUCLEOSIDES & NUCLEOTIDES, 1999, 18 (03): : 331 - 335
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Xie, Min
Lapidus, Rena G.
Sadowska, Mariola
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Hosmane, Ramachandra S.
BIOORGANIC & MEDICINAL CHEMISTRY, 2016, 24 (12) : 2595 - 2602
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NUCLEOSIDES & NUCLEOTIDES, 1994, 13 (10): : 2307 - 2320
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Zhang, Peng
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Hosmane, Ramachandra S.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2007, 17 (08) : 2225 - 2228
[20] Synthesis of a novel ring-expanded nucleoside analog containing the imidazo[4,5-e][1,3]diazepine ring system with a guanidinocarbamoyl-substituted cyclopropylidene group in place of a sugar moiety.
Chen, HM
Hosmane, RS
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