Myeloid-derived suppressor cells, age and cancer

被引：10
|
作者：
Bowdish, Dawn M. E. [1 ,2 ]
机构：
[1] McMaster Univ, McMaster Immunol Res Ctr, West Hamilton, ON, Canada
[2] McMaster Univ, MG DeGroote Inst Infect Dis Res, West Hamilton, ON, Canada
来源：
ONCOIMMUNOLOGY | 2013年 / 2卷 / 07期
关键词：
myeloid derived suppressor cells; immunosenescence; age; inflammation; tumor; INFLAMMATION; ACTIVATION; LONGEVITY;
D O I：
10.4161/onci.24754
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
We have recently discovered that the levels of circulating myeloid-derived suppressor cells, which are associated with an impaired T-cell proliferation and produce high amounts of reactive oxygen species, increase with age and are elevated in individuals in remission from cancer. Herein, potential mechanisms underpinning these observations are discussed.
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页数：2
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