Nitric oxide synthase inhibitor aminoguanidine potentiates iminodipropionitrile-induced neurotoxicity in rats

被引:9
|
作者
Tariq, M [1 ]
Khan, HA [1 ]
Al Deeb, S [1 ]
Al Moutaery, K [1 ]
机构
[1] Armed Forces Hosp, Neurosci Res Grp, Riyadh 11159, Saudi Arabia
关键词
iminodipropionitrile; aminoguanidine; nitric oxide; neurotoxicity; vestibular toxicity;
D O I
10.1016/S0304-3940(99)00789-2
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
This investigation was undertaken to study the effect of nitric oxide synthase inhibitor, aminoguanidine on iminodipropionitrile (IDPN)-induced neurobehavioral and vestibular toxicity in rats. The dyskinetic syndrome was produced in male Wistar rats by i.p. injections of IDPN (100 mg/kg) for 6 days. Aminoguanidine was administered orally in the doses of 50, 150 and 300 mg/kg, 60 min before IDPN in three different groups. Control rats received vehicle only, whereas another group was treated with 300 mg/kg of aminoguanidine alone (without IDPN). Our results showed that aminoguanidine significantly and dose dependently exacerbated the incidence and intensity of IDPN-induced dyskinetic head movements. Aminoguanidine potentiated IDPN-induced loss of air righting reflex. The histopathological examination of inner ear showed aggravation of IDPN-induced degeneration of sensory hair cells in the crista ampullaris by aminoguanidine. These results suggest the role of nitric oxide in IDPN-induced neurobehavioral and vestibular toxicity. (C) 1999 Published by Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码:49 / 52
页数:4
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