Intratumoral CYP27A1 expression in relation to cholesterol synthesis and vitamin D signaling and its association with lethal prostate cancer

被引：0
|
作者：
Khan, Nabeela A. [1 ]
Stopsack, Konrad H. [1 ]
Allott, Emma H. [2 ]
Gerke, Travis A. [3 ]
Giovannucci, Edward L. [4 ]
Mucci, Lorelei A. [4 ]
Kantoff, Philip W. [1 ]
机构：
[1] Mem Sloan Kettering Canc Ctr, 1275 York Ave, New York, NY 10021 USA
[2] Univ N Carolina, Chapel Hill, NC 27515 USA
[3] H Lee Moffitt Canc Ctr & Res Inst, Tampa, FL USA
[4] Harvard TH Chan Sch Publ Hlth, Boston, MA USA
来源：
CANCER RESEARCH | 2018年 / 78卷 / 13期
关键词：
D O I：
10.1158/1538-7445.AM2018-1450
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
1450
引用
收藏
页数：2
相关论文
共 50 条
  • [21] CYP27A1 expression is associated with risk of late lethal estrogen receptor-positive breast cancer in postmenopausal patients
    Siker Kimbung
    Maria Inasu
    Tor Stålhammar
    Björn Nodin
    Karin Elebro
    Helga Tryggvadottir
    Maria Ygland Rödström
    Karin Jirström
    Karolin Isaksson
    Helena Jernström
    Signe Borgquist
    Breast Cancer Research, 22
  • [22] Methylation in vitamin D metabolism enzyme genes (CYP2R1, CYP24A1, CYP27A1, CYP27B1) and the vitamin D receptor (VDR) gene in Cebu
    Perez, J.
    McDade, T. W.
    AMERICAN JOURNAL OF HUMAN BIOLOGY, 2018, 30 (02)
  • [23] Comprehensive association analysis of the vitamin D pathway genes, VDR, CYP27B1, and CYP24A1, in prostate cancer
    Holick, Crystal N.
    Stanford, Janet L.
    Kwon, Erika M.
    Ostrander, Elaine A.
    Nejentsev, Sergey
    Peters, Ulrike
    CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 2007, 16 (10) : 1990 - 1999
  • [24] CYP27A1, CYP24A1, and RXR-α Polymorphisms, Vitamin D, and Multiple Sclerosis: a Pilot Study
    Luisa Agnello
    Concetta Scazzone
    Bruna Lo Sasso
    Paolo Ragonese
    Salvatore Milano
    Giuseppe Salemi
    Marcello Ciaccio
    Journal of Molecular Neuroscience, 2018, 66 : 77 - 84
  • [25] Metabolism of 25-hydroxyvitamin D3 by microsomal and mitochondrial vitamin D3 25-hydroxylases (CYP2D25 and CYP27A1):: a novel reaction by CYP27A1
    Araya, Z
    Hosseinpour, F
    Bodin, K
    Wikvall, K
    BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 2003, 1632 (1-2): : 40 - 47
  • [26] CYP27A1, CYP24A1, and RXR- Polymorphisms, Vitamin D, and Multiple Sclerosis: a Pilot Study
    Agnello, Luisa
    Scazzone, Concetta
    Lo Sasso, Bruna
    Ragonese, Paolo
    Milano, Salvatore
    Salemi, Giuseppe
    Ciaccio, Marcello
    JOURNAL OF MOLECULAR NEUROSCIENCE, 2018, 66 (01) : 77 - 84
  • [27] Metabolism of cholesterol, vitamin D3 and 20-hydroxyvitamin D3 incorporated into phospholipid vesicles by human CYP27A1
    Tieu, Elaine W.
    Li, Wei
    Chen, Jianjun
    Baldisseri, Donna M.
    Slominski, Andrzej T.
    Tuckey, Robert C.
    JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2012, 129 (3-5): : 163 - 171
  • [28] Monocyte-derived cells express CYP27A1 and convert vitamin D3 into its active metabolite
    Gottfried, Eva
    Rehli, Michael
    Hahn, Joachim
    Holler, Ernst
    Andreesen, Reinhard
    Kreutz, Marina
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2006, 349 (01) : 209 - 213
  • [29] CYP27A1/27HC/SREBP2 axis is a novel therapeutic target in prostate cancer
    Alfaqih, M.
    Nelson, E. R.
    Liu, W.
    Safi, R.
    Jasper, J. S.
    Macias, E.
    Geradts, J.
    Chang, C. Y.
    McDonnell, D. P.
    Freedland, S.
    EUROPEAN JOURNAL OF CANCER, 2016, 69 : S42 - S43
  • [30] A Narrow-Band Ultraviolet B Course Improves Vitamin D Balance and Alters Cutaneous CYP27A1 and CYP27B1 mRNA Expression Levels in Haemodialysis Patients Supplemented with Oral Vitamin D
    Ala-Houhala, Meri J.
    Vahavihu, Katja
    Snellman, Erna
    Hasan, Taina
    Kautiainen, Hannu
    Karisola, Piia
    Dombrowski, Yvonne
    Schauber, Juergen
    Saha, Heikki
    Reunala, Timo
    NEPHRON CLINICAL PRACTICE, 2013, 124 (1-2): : 17 - 22
12345