GaCl3-Catalyzed C-H Cyanation of Indoles with N-Cyanosuccinimide

被引：16

作者：

Wang, Xue ^{[1
,2
]}

Makha, Mohamed ^{[2
]}

Chen, Shu-Wei ^{[1
]}

Zheng, Huaiji ^{[1
]}

Li, Yuehui ^{[2
]}

机构：

[1] Northwest A&F Univ, Coll Chem & Pharm, Yangling 712100, Shaanxi, Peoples R China

[2] Chinese Acad Sci, LICP, Suzhou Res Inst, State Key Lab Oxo Synth & Select Oxidat, Lanzhou 730000, Gansu, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2019年 / 84卷 / 10期

关键词：

CATALYZED DIRECT CYANATION; COPPER-MEDIATED CYANATION; DIRECT TRANSFORMATION; HIGHLY EFFICIENT; PRIMARY AMIDES; ARYL HALIDES; NITRILES; PYRROLES; CYANIDE; ARENES;

D O I：

10.1021/acs.joc.9b00416

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient GaCl3-catalyzed direct cyanation of indoles and pyrroles using bench-stable electrophilic cyanating agent N-cyanosuccinimide was achieved and afforded 3-cyanoindoles and 2-cyanopyrroles in good yields and excellent regioselectivities. Notably, this protocol exhibited high reactivity for unprotected indoles and was applicable to a broad range of indole and pyrrole substrates.

引用

页码：6199 / 6206

页数：8

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