High-speed AFM of human chromosomes in liquid

被引：38

作者：

Picco, L. M. ^{[1
,2
]}

Dunton, P. G. ^{[1
,2
]}

Ulcinas, A. ^{[1
,2
]}

Engledew, D. J. ^{[1
,2
]}

Hoshi, O. ^{[3
]}

Ushiki, T. ^{[3
]}

Miles, M. J. ^{[1
,2
]}

机构：

[1] Univ Bristol, HH Wills Phys Lab, Bristol BS8 1TL, Avon, England

[2] Univ Bristol, IRC Nanotechnol, Bristol BS8 1TL, Avon, England

[3] Niigata Univ, Div Microscop Anat & Bioimaging, Dept Cellular Funct, Grad Sch Med & Dent Sci, Niigata 9518150, Japan

来源：

NANOTECHNOLOGY | 2008年 / 19卷 / 38期

基金：

英国医学研究理事会; 英国工程与自然科学研究理事会;

关键词：

D O I：

10.1088/0957-4484/19/38/384018

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Further developments of the previously reported high-speed contact-mode AFM are described. The technique is applied to the imaging of human chromosomes at video rate both in air and in water. These are the largest structures to have been imaged with high-speed AFM and the first imaging in liquid to be reported. A possible mechanism that allows such high-speed contact-mode imaging without significant damage to the sample is discussed in the context of the velocity dependence of the measured lateral force on the AFM tip.

引用

页数：6

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