Cell cycle regulatory proteins in glomerular disease

被引：40
|
作者：
Shankland, SJ [1 ]
机构：
[1] Univ Washington, Div Nephrol, Seattle, WA 98195 USA
来源：
KIDNEY INTERNATIONAL | 1999年 / 56卷 / 04期
关键词：
glomerular growth; cell proliferation; hypertrophy; progressive glomerulosclerosis;
D O I：
10.1046/j.1523-1755.1999.00709.x
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
Evidence is accumulating that directly responsible for the rate of progression of glomerular disease are specific positive (cyclins and cyclin-dependent kinases) and negative (cyclin-kinase inhibitors) cell cycle regulatory proteins. The challenge for nephrologists is to determine which ones are expressed in renal disease and their precise role in glomerular cell proliferation, hypertrophy and differentiation. Ultimately the goal is to find ever more appropriate therapeutic strategies to arrest or prevent progressive renal disease.
引用
收藏
页码：1208 / 1215
页数：8
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