Effect of hemoperfusion on acute injury induced by acute organic phosphorus pesticide poisoning

Objective: This study is to investigate the effect of hemoperfusion (HP) on acute lung injury induced by acute organophosphorus pesticide poisoning (AOPP). Methods: A total of 64 cases of patients with AOPP induced acute pulmonary edema from January 2013 to June 2014 were enrolled in this study. The patients were randomly divided into control group (receiving conventional medical treatment) and HP group (receiving medical treatment + hemoperfusion treatment). At the time of 0 h, 24 h, 48 h and 72 h after hospitalization, chest X-ray, blood gas analysis, acetylcholinesterase (AChE) activity assay and percutaneous lung puncture biopsy were performed. Results: As the time went on, general clinical manifestations such as difficulty breathing in HP group was better compared with control group (P < 0.05). Chest X-ray showed that pulmonary edema in HP group was less serious than that in control group (P < 0.05). Blood gas analysis found that PO2 in HP group was higher whereas PCO2 was lower than those in control group (P < 0.05). Conclusion: HP treatment could reduce the incidence of acute pulmonary edema and increase the curative rate for AOPP patients.