Depletion of CD4-Effector Memory T Cells and Clonally Expanded IgG4 Memory B Cells May Explain the Therapeutic Efficacy of Rituximab in IgG4-Related Disease: Studies Using Flow Cytometry and Single-Cell Sequencing

被引:0
|
作者
Mattoo, Hamid [1 ]
Khosroshahi, Arezou
Mahajan, Vinay [1 ]
Carruthers, Mollie
Stone, John [1 ]
Pillai, Shiv
机构
[1] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Boston, MA USA
来源
ARTHRITIS AND RHEUMATISM | 2012年 / 64卷 / 10期
关键词
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
1752
引用
收藏
页码:S750 / S750
页数:1
相关论文
共 23 条
  • [1] Clonally expanded cytotoxic CD4+ T cells and the pathogenesis of IgG4-related disease
    Mattoo, Hamid
    Stone, John H.
    Pillai, Shiv
    AUTOIMMUNITY, 2017, 50 (01) : 19 - 24
  • [2] Intrathecal activation of CD8+ memory T cells in IgG4-related disease of the brain parenchyma
    Friedrich, Mirco
    Kehl, Niklas
    Engelke, Niko
    Kraus, Josephine
    Lindner, Katharina
    Muench, Philipp
    Mildenberger, Iris
    Groden, Christoph
    Gass, Achim
    Etminan, Nima
    Fatar, Marc
    von Deimling, Andreas
    Reuss, David
    Platten, Michael
    Bunse, Lukas
    EMBO MOLECULAR MEDICINE, 2021, 13 (08)
  • [3] Single-Cell RNA-Sequencing Reveals Peripheral T Helper Cells Promoting the Development of IgG4-Related Disease by Enhancing B Cell Activation and Differentiation
    Ji, Zongfei
    Lu, Weiqi
    Wu, Sifan
    Zhang, Yong
    Meng, Dan
    Zhang, Xiao
    Dai, Xiaojuan
    Chen, Huiyong
    Ma, Lili
    Sun, Ying
    Jiang, Lindi
    Kong, Xiufang
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 24 (18)
  • [4] Differential CpG DNA methylation of peripheral B cells, CD4+ T cells, and salivary gland tissues in IgG4-related disease
    Wu, Xunyao
    Wang, Anqi
    Wang, Mu
    Peng, Yu
    Chen, Yingying
    Li, Jieqiong
    Liu, Zheng
    Lu, Hui
    Zhou, Jiaxin
    Peng, Linyi
    Zhao, Yan
    Zeng, Xiaofeng
    Fei, Yunyun
    Zhang, Wen
    ARTHRITIS RESEARCH & THERAPY, 2023, 25 (01)
  • [5] Differential CpG DNA methylation of peripheral B cells, CD4+ T cells, and salivary gland tissues in IgG4-related disease
    Xunyao Wu
    Anqi Wang
    Mu Wang
    Yu Peng
    Yingying Chen
    Jieqiong Li
    Zheng Liu
    Hui Lu
    Jiaxin Zhou
    Linyi Peng
    Yan Zhao
    Xiaofeng Zeng
    Yunyun Fei
    Wen Zhang
    Arthritis Research & Therapy, 25
  • [6] Role of Lesional BCL6hiPD-1hi T Follicular Helper Cells As a Cardinal B-Cell Helper to Produce IgG4 in IgG4-Related Disease
    Kamekura, Ryuta
    Takano, Kenichi
    Yamamoto, Motohisa
    Kawata, Koji
    Jitsukawa, Sumito
    Nagaya, Tomonori
    Ito, Fumie
    Tsubomatsu, Chieko
    Takahashi, Hiroki
    Himi, Tetsuo
    Ichimiya, Shingo
    JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2017, 139 (02) : AB13 - AB13
  • [7] Expanded CD4+CXCR5-PD-1+peripheral T helper like cells and clinical significance in IgG4-related disease
    Zhang, Panpan
    Wang, Mu
    Chen, Yu
    Li, Jieqiong
    Liu, Zheng
    Lu, Hui
    Fei, Yunyun
    Feng, Ruie
    Zhao, Yan
    Zeng, Xiaofeng
    Zhang, Wen
    CLINICAL IMMUNOLOGY, 2022, 237
  • [8] Memory CD4+T Cell Signature Is Associated with Unfavorable Prognosis in IgG4-related Disease: Risk Stratification by Machine-learning
    Nie, Yuxue
    Liu, Zheng
    Cao, Wei
    Li, Taisheng
    Zhang, Wen
    ARTHRITIS & RHEUMATOLOGY, 2022, 74 : 3105 - 3105
  • [9] Memory CD4+T cell profile is associated with unfavorable prognosis in IgG4-related disease: Risk stratification by machine-learning
    Nie, Yuxue
    Liu, Zheng
    Cao, Wei
    Peng, Yu
    Lu, Hui
    Sun, Ruijie
    Li, Jingna
    Peng, Linyi
    Zhou, Jiaxin
    Fei, Yunyun
    Li, Mengtao
    Zeng, Xiaofeng
    Zhang, Wen
    Li, Taisheng
    CLINICAL IMMUNOLOGY, 2023, 252
  • [10] A CD8α- Subset of CD4+SLAMF7+Cytotoxic T Cells Is Expanded in Patients With IgG4-Related Disease and Decreases Following Glucocorticoid Treatment
    Della-Torre, Emanuel
    Bozzalla-Cassione, Emanuele
    Sciorati, Clara
    Ruggiero, Eliana
    Lanzillotta, Marco
    Bonfiglio, Silvia
    Mattoo, Hamid
    Perugino, Cory A.
    Bozzolo, Enrica
    Rovati, Lucrezia
    Arcidiacono, Paolo Giorgio
    Balzano, Gianpaolo
    Lazarevic, Dejan
    Bonini, Chiara
    Falconi, Massimo
    Stone, John H.
    Dagna, Lorenzo
    Pillai, Shiv
    Manfredi, Angelo A.
    ARTHRITIS & RHEUMATOLOGY, 2018, 70 (07) : 1133 - 1143