Expanded CD4+CXCR5-PD-1+peripheral T helper like cells and clinical significance in IgG4-related disease

被引：6

作者：

Zhang, Panpan ^{[1
,2
,3
,4
,5
]}

Wang, Mu ^{[6
]}

Chen, Yu ^{[7
]}

Li, Jieqiong ^{[1
,2
,3
,4
]}

Liu, Zheng ^{[1
,2
,3
,4
]}

Lu, Hui ^{[1
,2
,3
,4
]}

Fei, Yunyun ^{[1
,2
,3
,4
]}

Feng, Ruie ^{[8
]}

Zhao, Yan ^{[1
,2
,3
,4
]}

Zeng, Xiaofeng ^{[1
,2
,3
,4
]}

Zhang, Wen ^{[1
,2
,3
,4
]}

机构：

[1] Chinese Acad Med Sci & Peking Union Med Coll, Dept Rheumatol & Clin Immunol, Beijing 100730, Peoples R China

[2] Minist Sci & Technol, Natl Clin Res Ctr Dermatol & Immunol Dis NCRC DID, Beijing 100730, Peoples R China

[3] Peking Union Med Coll Hosp PUMCH, State Key Lab Complex Severe & Rare Dis, Beijing 100730, Peoples R China

[4] Minist Educ, Key Lab Rheumatol & Clin Immunol, Beijing 100730, Peoples R China

[5] Zhengzhou Univ, Affiliated Hosp 1, Dept Rheumatol & Immunol, Zhengzhou, Peoples R China

[6] Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Stomatol, Beijing, Peoples R China

[7] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Rheumatol, Wuhan, Peoples R China

[8] Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Pathol, Beijing, Peoples R China

来源：

CLINICAL IMMUNOLOGY | 2022年 / 237卷

基金：

中国国家自然科学基金;

关键词：

IgG4-RD; Tph like cells; Plasmablast; Disease monitoring; AUTOIMMUNE PANCREATITIS; DIAGNOSIS; COMBINATION; RELAPSE;

D O I：

10.1016/j.clim.2022.108975

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

To identify the phenotypic features and clinical significance of peripheral T helper (Tph) like cells in IgG4-RD, 54 untreated IgG4-RD patients and 57 healthy controls (HCs) were enrolled. Flow cytometry analysis, ELISA and correlation analysis were performed. Results indicated that percentages of CD4 + CXCR5-PD-1+ Tph like cells in the peripheral blood of IgG4-RD patients were significantly higher than those of HCs (2.27% +/- 1.99% vs 1.12% +/- 0.98%, P < 0.001). Expression of CD38, CD25, and TIGIT was higher, whereas that of CCR7, CD127 was lower in the Tph like cells from the IgG4-RD patients than in those from the HCs. The IgG4-RD patients with affected internal organs had higher circulating Tph like cell levels than those without (2.69% +/- 1.99% vs 1.23% +/- 0.93%, respectively, P = 0.003). In addition, Tph like cells correlated with serum IgG and IgG4 and peripheral plasmablast levels which could be a promising biomarker for disease activity monitoring.

引用

页数：9

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