Hypothesis: Poly-(R)-3-hydroxybutyrate is a major factor in intraocular pressure

被引：7

作者：

Norris, Vic ^{[1
]}

Bresson-Dumont, Helene ^{[2
]}

Gardea, Etienne ^{[3
]}

Reusch, Rosetta N. ^{[4
]}

Gruber, Denis ^{[3
]}

机构：

[1] Univ Rouen, Dept Biol, F-76821 Mont St Aignan, France

[2] Clin Sourdille, F-44000 Nantes, France

[3] CHU Charles Nicolle, Serv Ophtalmol, F-76000 Rouen, France

[4] Michigan State Univ, Dept Microbiol & Mol Genet, E Lansing, MI 48823 USA

来源：

MEDICAL HYPOTHESES | 2009年 / 73卷 / 03期

关键词：

OPEN-ANGLE GLAUCOMA; ESCHERICHIA-COLI; COUNTERION CONDENSATION; EXTRACELLULAR-MATRIX; PATHOGENESIS; TRANSPORT; DYNAMICS; CHANNEL; RISK; ACID;

D O I：

10.1016/j.mehy.2008.10.036

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Short chain poly-(R)-3-hydroxybutyrate (cPHB) is a ubiquitous molecule that readily adheres to others, that is covalently added to proteins and that forms, with polyphosphate, ion channels. High levels of cPHB have been implicated in atherosclerosis and in diabetes. Here, we propose a hypothesis in which cPHB adheres to filaments in the extracellular matrix and this raises intraocular pressure. In a corollary, we propose that a positive feedback relationship between cPHB adherence to filaments, raised IOP and filament stretching constitutes a switch. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：398 / 401

页数：4

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