Drimane Sesquiterpenoids from the Fungus Aspergillus ustus Isolated from the Marine Sponge Suberites domuncula

被引：74

作者：

Liu, Hongbing ^{[1
,8
]}

Edrada-Ebel, RuAngelie ^{[2
]}

Ebel, Rainer ^{[3
]}

Wang, Yao ^{[1
]}

Schulz, Barbara ^{[4
]}

Draeger, Siegfried ^{[4
]}

Mueller, Werner E. G. ^{[5
]}

Wray, Victor ^{[6
]}

Lin, Wenhan ^{[7
]}

Proksch, Peter ^{[1
]}

机构：

[1] Univ Dusseldorf, Inst Pharmazeut Biol & Biotechnol, D-40225 Dusseldorf, Germany

[2] Univ Strathclyde, Strathclyde Inst Pharm & Biomed Sci, Glasgow G4 0NR, Lanark, Scotland

[3] Univ Aberdeen, Dept Chem, Aberdeen AB24 3UE, Scotland

[4] Tech Univ Carolo Wilhelmina Braunschweig, Inst Mikrobiol, D-38106 Braunschweig, Germany

[5] Johannes Gutenberg Univ Mainz, Inst Physiol Chem & Pathobiochem, D-55128 Mainz, Germany

[6] Helmholtz Ctr Infect Res, D-38124 Braunschweig, Germany

[7] Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China

[8] Ocean Univ China, Sch Med & Pharm, Chinese Minist Educ, Key Lab Marine Drugs, Qingdao 266003, Peoples R China

来源：

JOURNAL OF NATURAL PRODUCTS | 2009年 / 72卷 / 09期

关键词：

BIOLOGICAL-ACTIVITY; METABOLITES;

D O I：

10.1021/np900220r

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Seven new drimane sesquiterpenoids (1-3, 6-9), along with the known compounds deoxyuvidin B (4), strobilactone B (5), and RES-1149-2 (10), were obtained from cultures of the fungus Aspergillus ustus, which was isolated from the marine sponge Suberites domuncula. Their structures were established by means of spectroscopic analyses including one- and two-dimensional NMR spectroscopy and high-resolution MS. Compounds 6, 7, and 10 showed cytotoxic activity against a panel of tumor cell lines, including L5178Y, HeLa, and PC12 cells, with 7 being the most active (EC50 against L5178Y cell line: 0.6 mu g/mL).

引用

页码：1585 / 1588

页数：4

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