Syntheses and absolute structures of novel protein farnesyltransferase inhibitors, Kurasoins A and B

被引:17
|
作者
Sunazuka, T
Hirose, T
Tian, ZM
Uchida, R
Shiomi, K
Harigaya, Y
Omura, S
机构
[1] KITASATO UNIV,BIOL FUNCT RES CTR,KITASATO INST,TOKYO 108,JAPAN
[2] KITASATO UNIV,SCH PHARMACEUT SCI,TOKYO 108,JAPAN
来源
JOURNAL OF ANTIBIOTICS | 1997年 / 50卷 / 05期
关键词
D O I
10.7164/antibiotics.50.453
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
引用
收藏
页码:453 / 455
页数:3
相关论文
共 50 条
  • [21] Potent inhibitors of protein farnesyltransferase: Heteroarenes as cysteine replacements
    Shen, W
    Fakhoury, S
    Donner, G
    Henry, K
    Lee, J
    Zhang, HC
    Cohen, J
    Warner, R
    Saeed, B
    Cherian, S
    Tahir, S
    Kovar, P
    Bauch, J
    Ng, SC
    Marsh, K
    Sham, H
    Rosenberg, S
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1999, 9 (05) : 703 - 708
  • [22] Protein farnesyltransferase inhibitors exhibit potent antimalarial activity
    Nallan, L
    Bauer, KD
    Bendale, P
    Rivas, K
    Yokoyama, K
    Hornéy, CP
    Pendyala, PR
    Floyd, D
    Lombardo, LJ
    Williams, DK
    Hamilton, A
    Sebti, S
    Windsor, WT
    Weber, PC
    Buckner, FS
    Chakrabarti, D
    Gelb, MH
    Van Voorhis, WC
    JOURNAL OF MEDICINAL CHEMISTRY, 2005, 48 (11) : 3704 - 3713
  • [23] Synthesis and antimalarial activity of novel peptidomimetic farnesyltransferase inhibitors
    Pusateri, EE
    Hamilton, AD
    Carrico, D
    Sebti, SM
    Gelb, MH
    Van Voorhis, WC
    Hucke, O
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2004, 228 : U113 - U113
  • [24] Farnesyltransferase and geranylgeranyltransferase I: structures, mechanism, inhibitors and molecular modeling
    Shen, Mingyun
    Pan, Peichen
    Li, Youyong
    Li, Dan
    Yu, Huidong
    Hou, Tingjun
    DRUG DISCOVERY TODAY, 2015, 20 (02) : 267 - 276
  • [25] Structure-activity relationship studies on thiaplidiaquinones A and B as novel inhibitors of Plasmodium falciparum and farnesyltransferase
    Cadelis, Melissa M.
    Bourguet-Kondracki, Marie-Lise
    Dubois, Joelle
    Kaiser, Marcel
    Brunel, Jean Michel
    Barker, David
    Copp, Brent R.
    BIOORGANIC & MEDICINAL CHEMISTRY, 2017, 25 (16) : 4433 - 4443
  • [26] Assessing the efficacy of protein farnesyltransferase inhibitors in mouse models of progeria
    Yang, Shao H.
    Chang, Sandy Y.
    Andres, Douglas A.
    Spielmann, H. Peter
    Young, Stephen G.
    Fong, Loren G.
    JOURNAL OF LIPID RESEARCH, 2010, 51 (02) : 400 - 405
  • [27] Discovery of a New Class of Protein Farnesyltransferase Inhibitors in the Arylthiophene Series
    Lethu, Sebastien
    Ginisty, Maryon
    Bosc, Damien
    Dubois, Joelle
    JOURNAL OF MEDICINAL CHEMISTRY, 2009, 52 (20) : 6205 - 6208
  • [28] Novel conformationally extended naphthalene-based inhibitors of farnesyltransferase
    Burns, CJ
    Guitton, JD
    Baudoin, B
    Lelievre, Y
    Duchesne, M
    Parker, F
    Fromage, N
    Commercon, A
    JOURNAL OF MEDICINAL CHEMISTRY, 1997, 40 (12) : 1763 - 1767
  • [29] Farnesyltransferase inhibitors - a novel approach in the treatment of advanced pancreatic carcinomas
    Dempke, WCM
    ANTICANCER RESEARCH, 2003, 23 (2A) : 813 - 818
  • [30] Synthetic Inhibitors of Galectins: Structures and Syntheses
    Denavit, Vincent
    Laine, Danny
    Tremblay, Thomas
    St-Gelais, Jacob
    Giguere, Denis
    TRENDS IN GLYCOSCIENCE AND GLYCOTECHNOLOGY, 2018, 30 (172) : SE21 - SE40