Tumor suppressor activities of the Fbw7 E3 ubiquitin ligase receptor

被引：7
|
作者：
Fuchs, SY [1 ]
机构：
[1] Univ Penn, Sch Vet Med, Dept Anim Biol, Philadelphia, PA 19104 USA
来源：
CANCER BIOLOGY & THERAPY | 2005年 / 4卷 / 05期
关键词：
Fbw7; tumor suppressor; p53; c-Jun; cyclin E; c-Myc; Notch; ubiquitin; E3; ligase; cancer;
D O I：
10.4161/cbt.4.5.1703
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The F-box protein Fbw7/Sel-10/hCdc4/Ago, which is known to regulate ubiquitination and degradation of numerous important regulators of cell division and death including I Notch, cyclin E, c-Jun and c-Myc, has been recently rediscovered as a p53-dependent tumor suppressor. Delineation of the mechanisms of Fbw7 anti-oncogenic activities and of its inactivation in human cancers is expected to gain an important insight into tumorigenesis.
引用
收藏
页码：506 / 508
页数：3
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