T-cell intracellular antigens in health and disease

被引：42

作者：

Sanchez-Jimenez, Carmen ^{[1
]}

Izquierdo, Jose M. ^{[1
]}

机构：

[1] Univ Autonoma Madrid, CSIC, Ctr Biol Mol Severo Ochoa, Madrid, Spain

来源：

CELL CYCLE | 2015年 / 14卷 / 13期

关键词：

cell death; embryogenesis; gene expression control; proliferation; TIA1; TIAR; tumorigenesis; Welander; RNA-BINDING PROTEINS; WELANDER DISTAL MYOPATHY; NECROSIS-FACTOR-ALPHA; STRESS GRANULE FORMATION; PROMOTING FACTOR TIA-1; AU-RICH ELEMENT; MESSENGER-RNA; SPLICING REGULATOR; RECOGNITION MOTIFS; GENE-EXPRESSION;

D O I：

10.1080/15384101.2015.1053668

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

T-cell intracellular antigen 1 (TIA1) and TIA1-related/like protein (TIAR/TIAL1) are 2 proteins discovered in 1991 as components of cytotoxic T lymphocyte granules. They act in the nucleus as regulators of transcription and pre-mRNA splicing. In the cytoplasm, TIA1 and TIAR regulate and/or modulate the location, stability and/or translation of mRNAs. As knowledge of the different genes regulated by these proteins and the cellular/biological programs in which they are involved increases, it is evident that these antigens are key players in human physiology and pathology. This review will discuss the latest developments in the field, with physiopathological relevance, that point to novel roles for these regulators in the molecular and cell biology of higher eukaryotes.

引用

页码：2033 / 2043

页数：11

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